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FGF-401

化学構造式
1708971-55-4
CAS番号.
1708971-55-4
化学名:
别名:
英語名:
FGF-401
英語别名:
Roblitinib;0997;FGF-401;FGF 401;FGF-401;Roblitinib（FGF-401）;FGF401( Roblitinib);FGF-401 ISO 9001：2015 REACH;8-naphthyridine-1(2H)-carboxamide;N-[5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide;N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide
CBNumber:
CB03166185
化学式:
C25H30N8O4
分子量:
506.56
MOL File:
1708971-55-4.mol

FGF-401 物理性質

沸点 :
852.1±65.0 °C(Predicted)
比重(密度) :
1.39±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO:5.4(Max Conc. mg/mL);10.66(Max Conc. mM)
Chloroform:30.0(Max Conc. mg/mL);59.22(Max Conc. mM)
外見 :
A crystalline solid
酸解離定数(Pka):
11.40±0.20(Predicted)
色:
White to off-white

安全性情報

FGF-401 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

FGF-401 化学特性,用途語,生産方法

説明

FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM). It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks. It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.

FGF-401 上流と下流の製品情報

原材料

準備製品

FGF-401 生産企業

Global( 107)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338
 stella@zetchem.com China 2141 58
BOC Sciences 		+1-631-485-4226
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HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
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Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
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Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
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CR Corporation Lomited
fred.wen@crcorporation.cn CHINA 12069 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3136 58

  スペクトルデータ(1HNMR)

FGF-401(1708971-55-4)1HNMR

1708971-55-4()キーワード:

ロキサデュスタット 4-[3-オキソ-3-(2-オキソ-2,3-ジヒドロベンゾオキサゾール-6-イル)プロピル]ピペラジン-1-カルボン酸3,5-ジクロロベンジル ダクトリシブ
  • 1708971-55-4
  • 8-naphthyridine-1(2H)-carboxamide
  • 0997
  • FGF-401
  • N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
  • N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide
  • Roblitinib（FGF-401）
  • FGF 401;FGF-401
  • N-[5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide
  • 1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-
  • FGF401( Roblitinib)
  • FGF-401 ISO 9001：2015 REACH
  • Roblitinib
  • N-{5-cyano-4-[(2-methoxyethyl)amino]pyridin-2-yl}-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-1,2,3,4-tetrahydro-1,8-naphthyridine-1-carboxamide
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