FGF-401

FGF-401 구조식 이미지
카스 번호:
1708971-55-4
상품명:
FGF-401
동의어(영문):
Roblitinib;0997;FGF-401;FGF 401;FGF-401;Roblitinib(FGF-401);FGF401( Roblitinib);FGF-401 ISO 9001:2015 REACH;8-naphthyridine-1(2H)-carboxamide;N-[5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide;N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide
CBNumber:
CB03166185
분자식:
C25H30N8O4
포뮬러 무게:
506.56
MOL 파일:
1708971-55-4.mol

FGF-401 속성

끓는 점
852.1±65.0 °C(Predicted)
밀도
1.39±0.1 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMSO:5.4(Max Conc. mg/mL);10.66(Max Conc. mM)
Chloroform:30.0(Max Conc. mg/mL);59.22(Max Conc. mM)
물리적 상태
결정성 고체
산도 계수 (pKa)
11.40±0.20(Predicted)
색상
White to off-white

안전

FGF-401 C화학적 특성, 용도, 생산

개요

FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM). It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks. It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.

FGF-401 준비 용품 및 원자재

원자재

준비 용품


FGF-401 공급 업체

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