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Gusacitinib

化学構造式
1425381-60-7
CAS番号.
1425381-60-7
化学名:
别名:
英語名:
Gusacitinib
英語别名:
ASN-002;GUSACITINIB;GUSACITINIB (ASN-002);ASN-002 (Gusacitinib;Syk,Janus kinase,Gusacitinib,Spleen tyrosine kinase,JAK,ASN 002,ASN002,Inhibitor,inhibit;1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile;4-Piperidineacetonitrile, 1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-;2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile
CBNumber:
CB03364604
化学式:
C24H28N8O2
分子量:
460.53
MOL File:
1425381-60-7.mol

Gusacitinib 物理性質

比重(密度) :
1.47±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO:100.0(Max Conc. mg/mL);217.14(Max Conc. mM)
外見 :
A crystalline solid
酸解離定数(Pka):
9.17±0.20(Predicted)
色:
Light yellow to yellow
InChIKey:
NLFLXLJXEIUQDL-UHFFFAOYSA-N
SMILES:
N1(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C3C(=O)NN=CC3=N2)CCC(CC#N)CC1

安全性情報

Gusacitinib 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

Gusacitinib 化学特性,用途語,生産方法

説明

Gusacitinib is an orally bioavailable, potent dual inhibitor of Janus kinases (JAK 1, 2, 3, and TYK2) and spleen tyrosine kinase (SYK) with 50% inhibitory concentrations (IC50 values) of 5 to 46 nM in biochemical assays. Gusacitinib targets both Th1 and Th2 inflammatory pathways, which are involved in CHE[1].

brand name

ASN-002, EN-3351

参考文献

[1] Pablo A. Jimenez MD . “Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study.” Journal of the American Academy of Dermatology 89 2 (2023): Pages 235-242.

Gusacitinib 上流と下流の製品情報

原材料

準備製品

Gusacitinib 生産企業

Global( 46)Suppliers
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Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 13720134139
 orders@jknbiochem.com China 5394 58

  スペクトルデータ(1HNMR)

ASN-002(1425381-60-7)1HNMR
  • 1425381-60-7
  • ASN-002
  • GUSACITINIB (ASN-002)
  • 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile
  • GUSACITINIB
  • 2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile
  • ASN-002 (Gusacitinib
  • 4-Piperidineacetonitrile, 1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-
  • Syk,Janus kinase,Gusacitinib,Spleen tyrosine kinase,JAK,ASN 002,ASN002,Inhibitor,inhibit
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