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Gusacitinib

Gusacitinib 구조식 이미지

카스 번호:: 1425381-60-7

상품명:: Gusacitinib

동의어(영문):: ASN-002;GUSACITINIB;GUSACITINIB (ASN-002);ASN-002 (Gusacitinib;Syk,Janus kinase,Gusacitinib,Spleen tyrosine kinase,JAK,ASN 002,ASN002,Inhibitor,inhibit;1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile;4-Piperidineacetonitrile, 1-[5,6-dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-;2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile

CBNumber:: CB03364604

분자식:: C24H28N8O2

포뮬러 무게:: 460.53

MOL 파일:: 1425381-60-7.mol

속성

안전

용도

공급 업체 46

Gusacitinib 속성

밀도: 1.47±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO:100.0(Max Conc. mg/mL);217.14(Max Conc. mM)

물리적 상태: 결정성 고체

산도 계수 (pKa): 9.17±0.20(Predicted)

색상: Light yellow to yellow

InChIKey: NLFLXLJXEIUQDL-UHFFFAOYSA-N

SMILES: N1(C2=NC(NC3=CC=C(N4CCC(O)CC4)C=C3)=C3C(=O)NN=CC3=N2)CCC(CC#N)CC1

안전

Gusacitinib C화학적 특성, 용도, 생산

개요

Gusacitinib is an orally bioavailable, potent dual inhibitor of Janus kinases (JAK 1, 2, 3, and TYK2) and spleen tyrosine kinase (SYK) with 50% inhibitory concentrations (IC50 values) of 5 to 46 nM in biochemical assays. Gusacitinib targets both Th1 and Th2 inflammatory pathways, which are involved in CHE[1].

상표명

ASN-002, EN-3351

참고 문헌

[1] Pablo A. Jimenez MD . “Oral spleen tyrosine kinase/Janus Kinase inhibitor gusacitinib for the treatment of chronic hand eczema: Results of a randomized phase 2 study.” Journal of the American Academy of Dermatology 89 2 (2023): Pages 235-242.

Gusacitinib 준비 용품 및 원자재

원자재

준비 용품

Gusacitinib 공급 업체

글로벌( 46)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4692	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Kaixin Chemical (Hong Kong) Limited	010-88886666-01 13112345678	loyson@tcypharm.com	China	595	55
Shanghai Taibao Pharmaceutical Technology Co., Ltd.	13816752554	1745533547@qq.com	China	129	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	13720134139 13720134139	orders@jknbiochem.com	China	5371	58