ダウノルビシン 化学特性,用途語,生産方法
用途
アントラサイクリン系抗生物質トポイソメラーゼⅡを阻害することにより抗がん作用を示す
効能
抗生物質, 抗悪性腫瘍薬, トポイソメラーゼII阻害薬
解説
ダウノルビシン，C27H29NO10(527.52)．ダウノマイシンともいう．放線菌Streptomyces peuciticusが産生するアンスラサイクリン系抗生物質．塩酸塩は赤色の針状晶．分解点188～190 ℃．[α]20D＋253°(メタノール)．λmax 234，252，290，480，495，532 nm(ε 35100，24350，8000，11300，11500，5900)．グラム陽性菌に有効であるが，制がん剤として急性白血病などの治療に用いる．LD50 15～20 mg/kg(マウス，静注)．
化学的特性
Daunomycin is a thin red, needle-shaped
material.
使用
Daunorubicin hydrochloride USP (Cerubidine) is used to traet acute lymphocytic and granulocytic leukemia; lymphomas.
適応症
Daunorubicin (Cerubidine)
is used to treat acute leukemias, while its structural analogue,
doxorubicin (Adriamycin) is extensively employed
against a broad spectrum of cancers. Although
the two drugs have similar pharmacological and toxicological
properties, doxorubicin is more potent against
most animal and human tumors and will be discussed in
greater detail.
定義
ChEBI: A natural product found in Actinomadura roseola.
一般的な説明
Anthracycline antibiotic. An anticancer agent.
安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data.
Human poison by ingestion. Experimental
poison by subcutaneous, intravenous, and
intraperitoneal routes. Experimental
teratogenic and reproductive effects. Human
mutation data reported. When heated to
decomposition it emits toxic fumes of NOx.
See also DAUNOMYCIN
HYDROCHLORIDE.
職業ばく露
An antibiotic. It is used as a medicine
for treating cancer.
輸送方法
UN3249 Medicine, solid, toxic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic
solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-
Poisonous materials, Technical Name Required.
廃棄物の処理
It is inappropriate and possi-
bly dangerous to the environment to dispose of expired or
waste drugs and pharmaceuticals by flushing them down
the toilet or discarding them to the trash. Household quanti-
ties of expired or waste pharmaceuticals may be mixed with
wet cat litter or coffee grounds, double-bagged in plastic,
discard in trash. Larger quantities shall carefully take into
consideration applicable DEA, EPA, and FDA regulations. If
possible return the pharmaceutical to the manufacturer for
proper disposal being careful to properly label and securely
package the material. Alternatively, the waste pharmaceuti-
cal shall be labeled, securely packaged and transported by a
state licensed medical waste contractor to dispose by burial
in a licensed hazardous or toxic waste landfill or incinerator.
Consult with environmental regulatory agencies for guidance
on acceptable disposal practices. Generators of waste con-
taining this contaminant (≥100 kg/mo) must conform with
EPA regulations governing storage, transportation, treatment,
and waste disposal.
ダウノルビシン 上流と下流の製品情報
原材料
Sky blue
streptomyces avermifilis
エリスロマイシン
D(+)-ぶどう糖一水和物
l-LEUCYL DAUNORUBICIN
(8S,10S)-8β-アセチル-7,8,9,10-テトラヒドロ-6,8,10α,11-テトラヒドロキシ-1-メトキシ-5,12-ナフタセンジオン
7-DEOXYDAUNOMYCINONE
Epirubicin
5,12-Naphthacenedione, 8-acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-, (8S,10R)-
ダウノルビシン塩酸塩
準備製品