ロスコビチン
ロスコビチン 物理性質
- 融点 :
- 106~107℃
- 沸点 :
- 577.5±60.0 °C(Predicted)
- 比重(密度) :
- 1.3
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO (最大 10mg/ml、加温) またはエタノール (最大 10mg/ml) に可溶。
- 外見 :
- 白からオフホワイトの固体
- 酸解離定数(Pka):
- 14.56±0.10(Predicted)
- 色:
- 白い
- 安定性::
- DMSO溶液またはエタノール溶液で-20°Cで最大3か月保存できます。
- InChIKey:
- BTIHMVBBUGXLCJ-OAHLLOKOSA-N
- CAS データベース:
- 186692-46-6(CAS DataBase Reference)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01W0118-0159 |
ロスコビチン 98.0+% (HPLC)
Roscovitine 98.0+% (HPLC) |
186692-46-6 |
1mg |
¥7700 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCR684000 |
ロスコビチン
Roscovitine |
186692-46-6 |
25mg |
¥67200 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
R7772 |
ロスコビチン ≥98% (TLC)
Roscovitine ≥98% (TLC) |
186692-46-6 |
1mg |
¥22800 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
R7772 |
ロスコビチン ≥98% (TLC)
Roscovitine ≥98% (TLC) |
186692-46-6 |
5mg |
¥91700 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01W0118-0159 |
ロスコビチン 98.0+% (HPLC)
Roscovitine 98.0+% (HPLC) |
186692-46-6 |
10mg |
¥38500 |
2024-03-01 |
購入 |
ロスコビチン 化学特性,用途語,生産方法
外観
白色~ほとんど白色, 結晶性粉末~粉末
溶解性
メタノール……1mg/mlDMSOに可溶エタノール及びアセトンに溶け、水に溶けない。
用途
アルツハイマー病研究用。
定義
ChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.
一般的な説明
A potent, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks) that exhibits about ten-fold greater efficacy towards p34
cdk1 and p33
cdk2 and twenty-fold greater efficacy towards p33
cdk5 relative to Olomoucine (Cat. No.
495620). Inhibits p34
cdk1/cyclin B (IC
50 = 650 nM), p33
cdk2/cyclin A (IC
50 = 700 nM), p33
cdk2/cyclin E (IC
50 = 700 nM), and p33
cdk5/p35 (IC
50 = 200 nM) by competing for the ATP binding domain of the kinases. Exhibits reduced sensitivity towards related kinases including ERK1 and ERK2 (IC
50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM, including p34
cdk4/cyclin D1 and p40
cdk6/cyclin D2. Compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G
1/S and G
2/M phases of the cell cycle. A 50 mM (5 mg/282 μl) solution of Roscovitine (Cat. No.
557364) in DMSO is also available.
抗がん研究
Roscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).
ロスコビチン 上流と下流の製品情報
原材料
準備製品
ロスコビチン 生産企業
Global( 216)Suppliers
186692-46-6(ロスコビチン)キーワード:
- 186692-46-6
- 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
- (2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol
- 2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
- 2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
- 6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE
- ROSCOVITINE
- (R)-ROSCOVITINE
- (R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE
- P34 CDC2
- R-ROSCOVITINE 98% (HPLC)
- ROSCOVITINE 95+%
- 1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-
- 2-(r)-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9h-purin-2-yl]amino]-1-butanol
- 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
- Roscovitine (CYC202,Seliciclib)
- 6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine Roscovitine
- Roscovitine,2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
- Roscovitine(CYC202)
- 2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-
- (R)-2-(1-ETHY
- Roscovitine (Seliciclib)
- (2R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
- (R)-2-[[9-(1-Methylethyl)-6-[(phenylMethyl)aMino]-9H-purin-2-yl]aMino]-1-butanol
- CYC 202
- Roscoviline
- Posiphe
- CYC-202(ROSCOVITINE)
- 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine
- 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine Roscovitine (Seliciclib,CYC202)
- Roscovitine
(R)-Roscovitine
- ロスコビチン
- (2S)-2-[6-(ベンジルアミノ)-9-(プロパン-2-イル)-9H-プリン-2-イル]ブタン-1-オール
- セリシクリブ
- (R)-2-[[6-(ベンジルアミノ)-9-イソプロピル-9H-プリン-2-イル]アミノ]-1-ブタノール
- 6-(ベンジルアミノ)-9-イソプロピル-N-[(R)-1-(ヒドロキシメチル)プロピル]-9H-プリン-2-アミン
- (R)-ロスコビチン
- (2R)-2-{[6-(ベンジルアミノ)-9-(プロパン-2-イル)-9H-プリン-2-イル]アミノ}ブタン-1-オール
- 2-[[(R)-1-(ヒドロキシメチル)プロピル]アミノ]-6-(ベンジルアミノ)-9-イソプロピル-9H-プリン
- 2-[(S)-1-エチル-2-ヒドロキシエチル]-9-イソプロピル-6-(ベンジルアミノ)-9H-プリン