(2-フェニルエチル)ヒドラジン 化学特性,用途語,生産方法
効能
抗うつ薬, モノアミン酸化酵素(MAO)阻害薬
説明
Monoamine oxidase inhibitors (MAOIs) were the first antidepressant
drugs introduced during the 1950s. Associated with
many side effects and, in particular, drug–drug and drug–food
interactions, their use declined with the subsequent introduction
of the tricyclic antidepressants and specific serotonin
reuptake inhibitors as first-line treatments for depression.
使用
Phenelzine is a MAO inhibitor which is used for treating patients with depressive characteristics such as “atypical,” “nonendogenous,” or “neurotic” conditions in which a combination of anxiety, depression, or phobia are observed. Phenelzine is not a drug of first
choice, and it is used in depressions that do not respond to other medicinal drugs.
作用機序
Phenelzine is a hydrazine MAOI. Its mechanism of action is the prolonged, nonselective,
irreversible inhibition of MAO. Phenelzine has been used with some success in the management of bulimia
nervosa. The MAOIs, however, are potentially dangerous in patients with binge eating and purging behaviors,
and the American Psychiatric Association states that MAOIs should be used with caution in the management
of bulimia nervosa.
安全性プロファイル
Poison by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: ataxia, somnolence. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Used as an antidepressant. When heated to decomposition it emits toxic fumes of NOx.
環境運命予測
MAOIs are available orally. Accidental or intentional ingestion
are the most common routes of exposure.
(2-フェニルエチル)ヒドラジン 上流と下流の製品情報
原材料
準備製品