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CD38 inhibitor 78c

化学構造式
1700637-55-3
CAS番号.
1700637-55-3
化学名:
别名:
英語名:
CD38 inhibitor 78c
英語别名:
78c;cd38-1;MDK7553;MDK 7553;MDK-7553;CD38i_78c;CD38IN-78c;CD38 IN-78c;CD38-IN-78c;Compound-78c
CBNumber:
CB04667733
化学式:
C22H27N3O3S
分子量:
413.53
MOL File:
1700637-55-3.mol

CD38 inhibitor 78c 物理性質

沸点 :
589.8±50.0 °C(Predicted)
比重(密度) :
1.27±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
外見 :
A solid
酸解離定数(Pka):
3.17±0.20(Predicted)
色:
Light yellow to brown
InChI:
InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChIKey:
VJQALSOBHVEJQM-QAQDUYKDSA-N
SMILES:
N1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O

安全性情報

CD38 inhibitor 78c 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

CD38 inhibitor 78c 化学特性,用途語,生産方法

説明

Thiazoloquin(az)olin(on)es, such as the small molecule 78c, have been identified as potent CD38 inhibitors (CD38i). CD38 inhibitor 78c is a potent, reversible, and uncompetitive inhibitor of CD38. 78c reverses age-related NAD+ decline and ameliorates several metabolic, structural, and molecular ageing features in chronologically aged and progeroid mice. The CD38 inhibitor 78c increases naturally aged mice's lifespan and health span. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between the sexes[1-2].

使用

4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone is a useful compound and has been evaluated for use as CD38 inhibitors.

CD38 inhibitor 78c 上流と下流の製品情報

原材料

準備製品

CD38 inhibitor 78c 生産企業

Global( 61)Suppliers
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  スペクトルデータ(1HNMR)

CD38 inhibitor 78c(1700637-55-3)1HNMR
  • 1700637-55-3
  • CD38 inhibitor 78c
  • CD38 inhibitor 1
  • 2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-
  • CD38 inhibitor 1 (compound 78c)
  • 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone
  • 4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one
  • cd38-1
  • CD38 inhibitor 1,Inhibitor,inhibit,CD-38 inhibitor 1
  • 4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)quinolin-2(1H)-one
  • 4- (trans 4- (2-methoxyethoxy) cyclohexyl) amino) -1-methyl-6- (thiazol-5-yl) quinoline-2 (1H) - one
  • CD38 IN-78c
  • CD38-IN-78c
  • CD38IN-78c
  • Cluster of Differentiation 38 Inhibitor
  • Compound-78c
  • MDK 7553
  • MDK7553
  • MDK-7553
  • 78c
  • CD38i_78c
  • CD38IN-78c: CD38 inhibitor 78c
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