4-(N-ニトロソメチルアミノ)-1-(3-ピリジニル)-1-ブタノン 化学特性,用途語,生産方法
化学的特性
Off-White Crystals
使用
This compound was present in the highest concentrations in smokeless tobacco out of the nitrosamines identified. Readily produces cancer in rats and hamsters
調製方法
NNK is not produced commercially. NNK is formed by
oxidation and nitrosation of nicotine and is produced during
the curing, aging, processing, and smoking of tobacco. NNK
has been found in tobacco at levels up to 35 mg/kg, in snuff up
to 8.3 mg/kg, and in cigarette smoke up to 0.5 mg per cigarette
(179, 193). Common cigarette filters considerably
reduce the amount of NNK that reaches the smoker. NNK
is extracted from snuff by the saliva of users, and as much as
0.2 μg/g of saliva has been measured. Potential exposure
to NNK is widespread also among those exposed to
sidestream smoke and has been detected at 0.2–15.7 μg/
cigarette. Evidence from one comparative study of
tobacco-specific nitrosamines in cigarettes suggests that
levels of NNK (measured as a sum of all tobacco-specific
nitrosamines) are higher in non-Moldovan cigarette tobacco
and Moldovan blended cigarettes, suggesting that current
tobacco production and manufacturing technologies may
create conditions that favor N-nitrosation of alkaloids and
other tobacco constituents.
一般的な説明
Pale yellow crystalline solid.
空気と水の反応
4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE may be sensitive to prolonged exposure to air and light.
反応プロフィール
A nitrated amine and ketone. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Ketones are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
火災危険
Flash point data for 4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE are not available; however, 4-(N-NITROSOMETHYLAMINO)-1-(3-PYRIDYL)-1-BUTANONE is probably combustible.
安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic and
neoplastigenic data. An experimental
teratogen. Mutation data reported. A
flammable liquid. When heated to
decomposition it emits toxic fumes of NOx.
発がん性
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
4-(N-ニトロソメチルアミノ)-1-(3-ピリジニル)-1-ブタノン 上流と下流の製品情報
原材料
準備製品