2,6-ジフルオロ-4-[2-(フェニルスルホニルアミノ)エチルチオ]フェノキシアセトアミド 化学特性,用途語,生産方法
使用
PEPA is an allosteric potentiator of AMPA desensitization.
生物活性
Novel allosteric potentiator of AMPA receptor desensitization. Slows the rate of onset of desensitization and potentiates steady-state equilibrium currents induced by glutamate with subunit (GluR3/4 > GluR1) and splice variant (flop > flip) selectivity. Ameliorates post-ischemic memory impairment in rats following i.v. administration.
Biochem/physiol Actions
2,6-Difluoro-4-[2-(phenylsul-fonyl-amino)-ethyl-thio]-phenoxy-acet-amide is a structurally novel, selective, high affinity AMPA ionotropic glutamate receptor agonist that reduces ischemia-induced performance deficits in rats.
2,6-ジフルオロ-4-[2-(フェニルスルホニルアミノ)エチルチオ]フェノキシアセトアミド 上流と下流の製品情報
原材料
準備製品