SB-505124 塩酸塩 水和物
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- CAS番号.
- 694433-59-5
- 化学名:
- SB-505124 塩酸塩 水和物
- 别名:
- SB-505124 塩酸塩 水和物;2-[4-(1,3-ベンゾジオキソール-5-イル)-2-(tert-ブチル)-1H-イミダゾール-5-イル]-6-メチルピリジン;5-[2-tert-ブチル-5-(2-メチル-6-ピリジル)-1H-イミダゾール-4-イル]-1,3-ベンゾジオキソール;2-[4-(2H-1,3-ベンゾジオキソール-5-イル)-2-tert-ブチル-1H-イミダゾール-5-イル]-6-メチルピリジン
- 英語名:
- 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
- 英語别名:
- CS-872;SB505124;SB505124;SB-505124 hydrochloride hydrate;SB-505124 hydrate hydrochloride;SB-505124 hydrochloride hydrate SB505124;SB-505124, 98%, a selective inhibitor of TGFβR for ALK4, ALK5;2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-iMidazol-4-yl)-6-Methylpyridine;2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine;2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine;2-[5-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-4-yl]-6-methylpyridine
- CBNumber:
- CB12100798
- 化学式:
- C20H21N3O2
- 分子量:
- 335.4
- MOL File:
- 694433-59-5.mol
- MSDS File:
- SDS
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SB-505124 塩酸塩 水和物 物理性質
- 融点 :
- 168 °C
- 沸点 :
- 509.7±50.0 °C(Predicted)
- 比重(密度) :
- 1.202
- 貯蔵温度 :
- Sealed in dry,2-8°C
- 溶解性:
- DMSO:>10mg/mL
- 酸解離定数(Pka):
- 11.26±0.10(Predicted)
- 外見 :
- 粉
- 色:
- 黄色
SB-505124 塩酸塩 水和物 価格
もっと(8)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3263 |
SB 505124 |
694433-59-5 |
10mg |
¥91000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3263 |
SB 505124 |
694433-59-5 |
50mg |
¥384000 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
S4696 |
SB-505124 塩酸塩 水和物 ≥98% (HPLC)
SB-505124 hydrochloride hydrate ≥98% (HPLC) |
694433-59-5 |
25mg |
¥146000 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
S4696 |
SB-505124 塩酸塩 水和物 ≥98% (HPLC)
SB-505124 hydrochloride hydrate ≥98% (HPLC) |
694433-59-5 |
5mg |
¥51100 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCS154680 |
SB-505124 |
694433-59-5 |
10mg |
¥55300 |
2023-06-01 |
購入 |
SB-505124 塩酸塩 水和物 化学特性,用途語,生産方法
外観
白色~うすい黄色~うすい黄赤色粉末~結晶
説明
SB-505124 inhibits the TGF-
β1 receptor serine/threonine kinase ALK5 with an IC
50 value of 47 nM. Though it is a less potent antagonist of ALK4 (IC
50 = 129 nM) and ALK7, SB-505124 selectively and concentration-
dependently inhibits ALK4-
, ALK5-
, and ALK7-
dependent activation of downstream SMAD2 and SMAD3 and TGF-
β–induced MAP kinase pathway components without altering ALK1-
3 or ALK6-
induced SMAD signaling. In an assay determining
in vitro phosphorylation of SMAD3, SB-505124 is more potent than SB-431452 with IC
50 values of 47
versus 94 nM, respectively.
使用
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptor ALK5 and as well as being a selective inhibitor of ALK4 but with less potency. SB-505124 blocks TGF-β–induced apoptosis of FaO cells and NRP 154 cells in a concentration-dependent manner. SB-505124 has been shown to suppress the migration and invasion of breast cancer MCF-7-M5 cells.
Biochem/physiol Actions
SB-505124 selectively inhibits TGF-β type I receptors, activin receptor-like kinases (ALK) 4, 5 and 7. It inhibits ALK4-, 5- and 7-mediated activation of Smad2, Smad3 and MAPK pathway induced by TGF-β.1 SB-505124 inhibits the human fibroblast trans-differentiation induced by the co-culture with Esophageal squamous cell carcinoma.2
SB-505124 塩酸塩 水和物 上流と下流の製品情報
原材料
準備製品
SB-505124 塩酸塩 水和物 生産企業
Global( 118)Suppliers
SB-505124 塩酸塩 水和物 スペクトルデータ(1HNMR)
694433-59-5(SB-505124 塩酸塩 水和物)キーワード:
- 694433-59-5
- 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride
- SB-505124 hydrate hydrochloride
- 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-iMidazol-4-yl)-6-Methylpyridine
- 2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1- diMethylethyl)-1H-iMidazol-5-yl]-6-Methyl-pyridine
- 2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine
- SB-505124 hydrochloride hydrate
- 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine
- 2-[4-(1,3-Benzodioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl]-6-methylpyridine SB505124
- 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride hydrate
- SB505124;SB505124
- SB-505124, 98%, a selective inhibitor of TGFβR for ALK4, ALK5
- CS-872
- Pyridine, 2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-
- 2-[5-(Benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-4-yl]-6-methylpyridine
- SB-505124 hydrochloride hydrate SB505124
- SB-505124 塩酸塩 水和物
- 2-[4-(1,3-ベンゾジオキソール-5-イル)-2-(tert-ブチル)-1H-イミダゾール-5-イル]-6-メチルピリジン
- 5-[2-tert-ブチル-5-(2-メチル-6-ピリジル)-1H-イミダゾール-4-イル]-1,3-ベンゾジオキソール
- 2-[4-(2H-1,3-ベンゾジオキソール-5-イル)-2-tert-ブチル-1H-イミダゾール-5-イル]-6-メチルピリジン