SB-366791 化学特性,用途語,生産方法
外観
白色~うすい褐色, 結晶~粉末
溶解性
アセトンに溶け、水にほとんど溶けない。
使用
N-(4-Methoxyphenyl)-4-chlorocinnamamide is a novel, potent, and selective cinnamide TRPV1 antagonist. Also a useful tool to further study the biology of TRPV1.
生物活性
Potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
Biochem/physiol Actions
SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.
SB-366791 上流と下流の製品情報
原材料
準備製品