N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド
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- CAS番号.
- 926908-04-5
- 化学名:
- N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド
- 别名:
- N-ヒドロキシ-7-(ナフタレン-2-イルスルファニル)ヘプタンアミド;N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド;N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタンアミド
- 英語名:
- HNHA
- 英語别名:
- HNHA;HNHAHDAC inhibitor;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide;Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-;Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
- CBNumber:
- CB12514669
- 化学式:
- C17H21NO2S
- 分子量:
- 303.42
- MOL File:
- 926908-04-5.mol
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N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド 物理性質
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2-8°C
- 溶解性:
- ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
- 外見 :
- Crystalline solid
- 色:
- White to off-white
- Sensitive :
- Light Sensitive
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド 価格
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製品説明 |
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N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド 化学特性,用途語,生産方法
説明
HNHA is a cell-
permeable inhibitor of histone deacetylase (HDAC) activity (IC
50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC
50 ~ 7.5 μM). HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model
in vivo. HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.
使用
A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity
N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド 上流と下流の製品情報
原材料
準備製品
N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド 生産企業
Global( 39)Suppliers
N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド スペクトルデータ(1HNMR)
- 926908-04-5
- HNHAHDAC inhibitor
- HNHA
- N-hydroxy-7-(2-naphthalenylthio)-Heptanamide
- Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-
- N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide
- Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
- N-ヒドロキシ-7-(ナフタレン-2-イルスルファニル)ヘプタンアミド
- N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタノミド
- N-ヒドロキシ-7-(2-ナフチルチオ)ヘプタンアミド