HNHA
- CAS No.
- 926908-04-5
- Chemical Name:
- HNHA
- Synonyms
- HNHA;HNHAHDAC inhibitor;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide;Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-;Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
- CBNumber:
- CB12514669
- Molecular Formula:
- C17H21NO2S
- Molecular Weight:
- 303.42
- MDL Number:
- MFCD10568146
- MOL File:
- 926908-04-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P302+P352-P305+P351+P338-P321-P405-P501 |
HNHA price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J64917 | HNHA | 926908-04-5 | 10mg | $167 | 2021-12-16 | Buy |
Cayman Chemical | 13295 | HNHA ≥98% | 926908-04-5 | 5mg | $85 | 2024-03-01 | Buy |
Cayman Chemical | 13295 | HNHA ≥98% | 926908-04-5 | 10mg | $158 | 2024-03-01 | Buy |
Cayman Chemical | 13295 | HNHA ≥98% | 926908-04-5 | 25mg | $374 | 2024-03-01 | Buy |
AK Scientific | 1789AH | HNHA | 926908-04-5 | 25mg | $513 | 2021-12-16 | Buy |
HNHA Chemical Properties,Uses,Production
Description
HNHA is a cell-
Uses
A cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity
Definition
ChEBI: N-hydroxy-7-(2-naphthalenylthio)heptanamide is a member of naphthalenes.
in vitro
previous study found that hnha was able to inhibit in-vitro hdac enzyme activity as well as proliferation of human fibrosarcoma cells (ht1080). in addition, treatment of cells with hnha could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of ht1080 cell invasion [1].
in vivo
the effects of hnha on human cancer cells bearing xenograph mice was examined. results showed that as expected, hnha could dramatically reduce tumor volume as to (vehicle) control. in addition, hnha had a stronger potency than that of saha, which implied that the pharmacological potency of hnha was better than saha in vivo [1].
IC 50
100 nm
References
1. kim, d.h.,lee, j.,kim, k.n., et al. anti-tumor activity of n-hydroxy-7-(2-naphthylthio) heptanomide, a novel histone deacetylase inhibitor. biochemical and biophysical research communications 356, 233-238 (2007).
HNHA Preparation Products And Raw materials
Raw materials
Preparation Products
HNHA Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18657 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
Tianjin Derchemist Science & Technology Co., Ltd. | 22-58627059 13920586291 | zdcomcon@126.com | China | 3296 | 50 |
Aikon International Limited | 025-66028182 18112977050 | cfzhang@aikonchem.com | China | 15820 | 58 |
Henan Weituxi Chemical Technology Co., Ltd. | 0371-63284658 18135795563 | 2885349392@qq.com | China | 10006 | 58 |
Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49323 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 63720 | 58 |