HNHA
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- $54 - $513
- Product name: HNHA
- CAS: 926908-04-5
- MF: C17H21NO2S
- MW: 303.42
- EINECS:-0
- MDL Number:MFCD10568146
- Synonyms:HNHAHDAC inhibitor;HNHA;N-hydroxy-7-(2-naphthalenylthio)-Heptanamide;Heptanamide, N-hydroxy-7-(2-naphthalenylthio)-;N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide;Histone deacetylases,HIF/HIF Prolyl-Hydroxylase,inhibit,HNHA,Inhibitor,HIF-PH,HIFs,FM3A cells,MCF-7 cells,Anti-cancer activity,Matrix metalloproteinases,Breast cancer,Hypoxia-inducible factors,MMP,HDAC
10 prices
Selected condition：
Brand
- AK Scientific
- Alfa Aesar
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
Package
- 5mg
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number1789AH
- Product descriptionHNHA
- Packaging25mg
- Price$513
- Updated2021-12-16
- Buy
- ManufacturerAlfa Aesar
- Product numberJ64917
- Product descriptionHNHA
- Packaging10mg
- Price$167
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA729951
- Product descriptionN-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95%
- Packaging5mg
- Price$54
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA729951
- Product descriptionN-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95%
- Packaging10mg
- Price$102
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA729951
- Product descriptionN-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95%
- Packaging25mg
- Price$242
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001193
- Product descriptionN-HYDROXY-7-(2-NAPHTHALENYLTHIO)-HEPTANAMIDE 95.00%
- Packaging5MG
- Price$198
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4305
- Product descriptionHNHA
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13295
- Product descriptionHNHA ≥98%
- Packaging5mg
- Price$85
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13295
- Product descriptionHNHA ≥98%
- Packaging10mg
- Price$158
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13295
- Product descriptionHNHA ≥98%
- Packaging25mg
- Price$374
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1789AH | HNHA | 25mg | $513 | 2021-12-16 | Buy |
| Alfa Aesar | J64917 | HNHA | 10mg | $167 | 2021-12-16 | Buy |
| Ambeed | A729951 | N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95% | 5mg | $54 | 2021-12-16 | Buy |
| Ambeed | A729951 | N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95% | 10mg | $102 | 2021-12-16 | Buy |
| Ambeed | A729951 | N-Hydroxy-7-(naphthalen-2-ylthio)heptanamide 95% | 25mg | $242 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001193 | N-HYDROXY-7-(2-NAPHTHALENYLTHIO)-HEPTANAMIDE 95.00% | 5MG | $198 | 2021-12-16 | Buy |
| ApexBio Technology | C4305 | HNHA | 5mg | $95 | 2021-12-16 | Buy |
| Cayman Chemical | 13295 | HNHA ≥98% | 5mg | $85 | 2024-03-01 | Buy |
| Cayman Chemical | 13295 | HNHA ≥98% | 10mg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 13295 | HNHA ≥98% | 25mg | $374 | 2024-03-01 | Buy |
Properties
storage temp. :under inert gas (nitrogen or Argon) at 2-8°C
solubility :≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :Crystalline solid
color :White to off-white
Sensitive :Light Sensitive
solubility :≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form :Crystalline solid
color :White to off-white
Sensitive :Light Sensitive
Safety Information
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Description
HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~ 7.5 μM). HNHA is at least as effective as SAHA in inhibiting tumor growth in a murine xenograph model in vivo. HNHA also blocks the growth of human umbilical vein endothelial cells (HUVECs) and prevents tube formation and migration of HUVECs in response to vascular endothelial growth factor (VEGF). It also blocks retinal neovascularization and choroidal angiogenesis in mice.Suppliers and manufacturers
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