JZL 184 水和物
JZL 184 水和物 物理性質
- 融点 :
- 116-120°C
- 沸点 :
- 706.4±60.0 °C(Predicted)
- 比重(密度) :
- 1.467±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO に可溶 (最大 25 mg/ml)。
- 外見 :
- 白からオフホワイトの固体
- 酸解離定数(Pka):
- 13.32±0.29(Predicted)
- 色:
- 薄黄色~黄緑色
- 安定性::
- 購入日から2年間安定です。この DMSO 溶液は、-20°C で 2 か月間保存できます。
- CAS データベース:
- 1101854-58-3
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
RIDADR |
UN 2811 6.1 / PGIII |
|
|
HSコード |
29349990 |
|
|
絵表示(GHS) |
|
注意喚起語 |
危険 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
|
注意書き |
P301+P310 |
飲み込んだ場合:直ちに医師に連絡すること。 |
|
JZL 184 水和物 価格
もっと(7)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01CAY13158 |
JZL 184 |
1101854-58-3 |
5mg |
¥12300 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01CAY13158 |
JZL 184 |
1101854-58-3 |
10mg |
¥20700 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01CAY13158 |
JZL 184 |
1101854-58-3 |
100mg |
¥154800 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3836 |
JZL 184 |
1101854-58-3 |
10mg |
¥52000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3836 |
JZL 184 |
1101854-58-3 |
50mg |
¥184000 |
2024-03-01 |
購入 |
JZL 184 水和物 化学特性,用途語,生産方法
説明
Endocannabinoids such as 2-
arachidonoyl glycerol (2-
AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-
AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC
50 values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-
AG levels by 8-
fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB
1) agonists.
使用
JZL 184 hydrate has been used as an inhibitor of monoacylglycerol lipase to study its effect on human osteoblast differentiation and proliferation and postsynaptic neurons.
Biochem/physiol Actions
JZL184 selectively inhibits MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes. JZL 184 is the first selective inhibitor of MAGL with nanomolar portency and over 200-fold selectivity for MAGL vs FAAH. When administered to mice, JZL184 increased levels of 2-arachidonoylglycerol in the brain by about 8-fold, with no effect on levels of anandamide.
JZL 184 水和物 上流と下流の製品情報
原材料
準備製品
JZL 184 水和物 生産企業
Global( 99)Suppliers
JZL 184 水和物 スペクトルデータ(1HNMR)
1101854-58-3(JZL 184 水和物)キーワード:
- 1101854-58-3
- 4-Nitrophenyl 4-[bis(1,3-benzodioxol-5-yl)(hydroxy)Methyl]-1-piperidinecarboxylate
- 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester
- 1-Piperidinecarboxylic acid, 4-[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-, 4-nitrophenyl ester
- 4-[Bis(1,3-benzodioxol-5-yl)hydroxymethyl]-1-piperidinecarboxylic acid 4-nitrophenyl ester JZL 184
- JZL 184
- JZL 184 JZL184 JZL-184
- MAGL Inhibitor III, JZL184 - CAS 1101854-58-3 - Calbiochem
- JZL-184; JZL 184
- CS-815
- CS-1861
- JZL 184 ?JZL184 ?JZL-184 ?(4-Nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
- 1-Piperidinecarboxylicacid,4-Chemicalbook[bis(1,3-benzodioxol-5-yl)hydroxymethyl]-,4-nitrophenylester
- JZL184 (with 15% inorganics)
- 4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate