CYP3サイド 化学特性,用途語,生産方法
用途
CYP3A4 の強力で選択的阻害剤です（IC50 = 0.03 μM（CYP3A4），17 μM（CYP3A5），70 μM
（CYP3A7））。
用途
CYP3A4 の強力で選択的阻害剤です（IC50 = 0.03 μmol/l（CYP3A4），17 μmol/l（CYP3A5），
70 μmol/l（CYP3A7））。
化学的特性
White to Off-White Solid
使用
CYP3cide is a potent and selective time dependent inactivator of Cytochrome P450 3A4 (CYP3A4). CYP3A4 is an important enzymes involved in the metabolism of xenobiotics in the human body and constitutes to about a quarter of all CYPs in the human body. CYP3cide provides a useful in vitro tool in defining the individual roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.
Biochem/physiol Actions
CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4 that can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism. The IC50 values for inhibition of Midazolam 1′-Hydroxylase activity of recombinant CYP3A4 and CYP3A5 by CYP3cide are 0.3 and 17 mM, respectively.
CYP3サイド 上流と下流の製品情報
原材料
準備製品