CYP3cide

CYP3cide 구조식 이미지
카스 번호:
1390637-82-7
상품명:
CYP3cide
동의어(영문):
CYP3cide;PF-4981517;PF-04981517;CYP3cide USP/EP/BP;CYP3cide, PF-04981517;CYP3cide DISCONTINUED;PF 04981517 - CYP3cide | PF 4981517;1-methyl-3-[1-methyl-5-(4-methylphenyl)pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]pyrazolo[3,4-d]pyrimidine;1-Methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyrrolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidine, 1-methyl-3-[1-methyl-5-(4-methylphenyl)-1H-pyrazol-4-yl]-4-[(3S)-3-(1-piperidinyl)-1-pyrrolidinyl]-
CBNumber:
CB12620906
분자식:
C26H32N8
포뮬러 무게:
456.59
MOL 파일:
1390637-82-7.mol

CYP3cide 속성

끓는 점
630.2±55.0 °C(Predicted)
밀도
1.34±0.1 g/cm3(Predicted)
저장 조건
room temp
용해도
DMSO에 용해됨
물리적 상태
가루
산도 계수 (pKa)
8.88±0.20(Predicted)
색상
흰색에서 베이지색

안전

WGK 독일 3

CYP3cide C화학적 특성, 용도, 생산

화학적 성질

White to Off-White Solid

용도

CYP3cide is a potent and selective time dependent inactivator of Cytochrome P450 3A4 (CYP3A4). CYP3A4 is an important enzymes involved in the metabolism of xenobiotics in the human body and constitutes to about a quarter of all CYPs in the human body. CYP3cide provides a useful in vitro tool in defining the individual roles of CYP3A4 versus CYP3A5 in the metabolism of drugs.

Biochem/physiol Actions

CYP3cide is a mechanism-based inhibitor of cytochrome P4503A4 that can be used to distinguish the contributions of CYP3A4 versus CYP3A5 on drug metabolism. The IC50 values for inhibition of Midazolam 1′-Hydroxylase activity of recombinant CYP3A4 and CYP3A5 by CYP3cide are 0.3 and 17 mM, respectively.

CYP3cide 준비 용품 및 원자재

원자재

준비 용품


CYP3cide 공급 업체

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InvivoChem
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
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Chemsky(shanghai)International Co.,Ltd. 021-50135380
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Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826
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ApexBio Technology LLC +1-832-696-8203
info@apexbt.com United States 477 60

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