シナルカスト 化学特性,用途語,生産方法
効能
喘息治療薬, ロイコトリエン受容体拮抗薬
定義
ChEBI: 2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in th
human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma.
生物活性
Potent, selective CysLT 1 (LTD 4 ) leukotriene receptor antagonist (IC 50 = 6.4 nM). Inhibits LTD 4 -induced bronchoconstriction in guinea pigs when administered intravenously, orally or by aerosol.
シナルカスト 上流と下流の製品情報
原材料
準備製品