ガドベルセタミド 化学特性,用途語,生産方法
効能
診断補助薬 (常磁性造影剤, 脳疾患, 脊柱疾患)
説明
The contrast agent gadoversetamide was launched in the US as a solution for i.v.
injection to be used prior to magnetic resonance imaging (MRI) in patients with anomalous
blood-brain barrier or anomalous vascularity in the central nervous system or in the liver.
This chelate obtained by complexation of paramagnetic gadolinium(III) ion and DTPA-bis-
(methoxyethylamide) ligand enhances visualization of lesions including tumors in the brain,
spine and liver due to the effect of Gd(III)-water interaction on the proton magnetic
relaxation of water. The small molecular size gadoversetamide belongs to the class of
extracellular contrast agents. A phase III, multicenter, double-blind, parallel group trial
showed that gadoversetamide was well tolerated and as efficient as gadopentetate
dimeglumine (Schering) in hepatic magnetic resonance imaging of patients with suspected
liver pathology.
使用
Diagnostic aid (paramagnetic, brain disorders; spine disorders.
定義
ChEBI: A gadolinium coordination entity that consists of Gd3+ coordinated to 3,6,9-triazaundecadiamide in which each of the amide nitrogens is substituted by a 2-methoxyethyl group and in which the nitrogens at positions 3, 6, and 9 are each
ubstituted by carboxylatomethyl group. The gadolinium is coordinated to the three tertiary amino groups as well as to the carboxylate groups. A white odourless powder that is freely soluble in water, gadoversetamide has paramagnetic properties and is used
s a contrast agent in magnetic resonance imaging. It distributes mainly in extracellular fluid, but does not cross the blood-brain barrier. It is used particularly in imaging the brain, spine and liver.
ガドベルセタミド 上流と下流の製品情報
原材料
準備製品