4,5,6,7-テトラブロモベンズイミダゾール
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- CAS番号.
- 577779-57-8
- 化学名:
- 4,5,6,7-テトラブロモベンズイミダゾール
- 别名:
- 4,5,6,7-テトラブロモベンズイミダゾール
- 英語名:
- TBBZ
- 英語别名:
- 4,5,6,7-tetrabromo-1H-benzimidazole;1H-Benzimidazole, 4,5,6,7-tetrabromo-;4,5,6,7-tetrabromo-1H-benzo[d]imidazole;4,5,6,7-tetrabromo-1H-benzo[d]imidazole(WXC06733)
- CBNumber:
- CB1972937
- 化学式:
- C7H2Br4N2
- 分子量:
- 433.72
- MOL File:
- 577779-57-8.mol
- MSDS File:
- SDS
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4,5,6,7-テトラブロモベンズイミダゾール 物理性質
- 融点 :
- 330-332°C
- 沸点 :
- 553.5±45.0 °C(Predicted)
- 比重(密度) :
- 2.713±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO: >10mg/mL、60°C、透明
- 外見 :
- 粉
- 酸解離定数(Pka):
- 6.73±0.30(Predicted)
4,5,6,7-テトラブロモベンズイミダゾール 価格
もっと(5)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TRCT291150 |
4,5,6,7-テトラブロモベンズイミダゾール
4,5,6,7-Tetrabromobenzimidazole |
577779-57-8 |
25mg |
￥42000 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式会社(wako)
|
W01TRCT291150 |
4,5,6,7-テトラブロモベンズイミダゾール
4,5,6,7-Tetrabromobenzimidazole |
577779-57-8 |
10mg |
￥26700 |
2023-06-01 |
購入 |
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Sigma-Aldrich Japan
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T6951 |
≥98% (HPLC), powder
TBBz ≥98% (HPLC), powder |
577779-57-8 |
5mg |
￥27500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
T6951 |
≥98% (HPLC), powder
TBBz ≥98% (HPLC), powder |
577779-57-8 |
25mg |
￥105000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCT291150 |
4,5,6,7-テトラブロモベンズイミダゾール
4,5,6,7-Tetrabromobenzimidazole |
577779-57-8 |
250mg |
￥326700 |
2024-03-01 |
購入 |
4,5,6,7-テトラブロモベンズイミダゾール 化学特性,用途語,生産方法
化学的特性
Light Yellow Solid
使用
TBBz has been used as a CK2 inhibitor in HeLa cells and rat septal neurons.
Biochem/physiol Actions
TBBz is a cell-permeable Casein Kinase-2 (CK2) inhibitor. CK2 inhibitors, 4,5,6,7-tetrabromobenzotriazole (TBBt, Sigma Cat. # T0826) and rabromobenzimidazole (TBBz), the latter of which was shown to discriminate between different molecular forms of CK2 in yeast. TBBt, with a pK(a) ~5, exists in solution at physiological pH almost exclusively (>99%) as the monoanion; whereas TBBz, with a pKa ~9, is predominantly (>95%) in the neutral form, both of obvious relevance to their modes of binding. In vitro, TBBt inhibits different forms of CK2 with Ki values ranging from 80 to 210 nM. TBBz discriminates better between CK2 forms, with Ki values ranging from 70-510 nM. TBBz is more effective than TBBt in inducing apoptosis and to a lesser degree, necrosis in transformed human cell lines. Dvelopment of shRNA strategies for the selective knockdown of the CK2α and CK2α′ isoforms reinforces the foregoing results, indicating that inhibition of CK2 leads to attenuation of proliferation.
4,5,6,7-テトラブロモベンズイミダゾール 上流と下流の製品情報
原材料
準備製品
4,5,6,7-テトラブロモベンズイミダゾール 生産企業
Global( 28)Suppliers
577779-57-8(4,5,6,7-テトラブロモベンズイミダゾール)キーワード:
- 577779-57-8
- 4,5,6,7-tetrabromo-1H-benzimidazole
- 4,5,6,7-tetrabromo-1H-benzo[d]imidazole
- 4,5,6,7-tetrabromo-1H-benzo[d]imidazole(WXC06733)
- 1H-Benzimidazole, 4,5,6,7-tetrabromo-
- 4,5,6,7-テトラブロモベンズイミダゾール