アジルサルタン

アジルサルタン 価格 もっと(21)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01COBQA-3478	アジルサルタン Azilsartan	147403-03-0	1g	￥10000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQA-3478	Azilsartan	147403-03-0	25g	￥170000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQA-3478	Azilsartan	147403-03-0	100g	￥600000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01COBQA-3478	アジルサルタン Azilsartan	147403-03-0	10g	￥126000	2023-06-01	購入
東京化成工業	A2601	アジルサルタン >98.0%(HPLC)(T) Azilsartan >98.0%(HPLC)(T)	147403-03-0	200mg	￥9900	2023-06-01	購入

アジルサルタン 化学特性,用途語,生産方法

外観

白色～ほとんど白色粉末～結晶

用途

アンジオテンシンⅡ受容体拮 抗剤です。アンジオテンシンⅡ受容体タイプ Ⅰ（AT1）受容体に作用を示します。

用途

アジルサルタン（Azilsartan、開発コードTAK-536）は、武田薬品工業が開発したアンジオテンシンII受容体拮抗薬であり、高血圧の治療に用いられる。
アジルサルタンは血圧上昇ホルモンであるアンジオテンシンIIの受容体を阻害して抗血圧上昇作用を示す。

効能

血圧降下薬, アンジオテンシンII受容体拮抗薬

商品名

アジルバ (武田薬品工業)

説明

Azilsartan is an antagonist of the angiotensin II type 1 receptor (AT₁; IC₅₀ = 0.42 μM) and the active metabolite of azilsartan medoxomil . Azilsartan is formed from azilsartan medoxomil by hydrolysis in the gastrointestinal tract and liver. Azilsartan also acts as an inverse agonist, inhibiting angiotensin II-induced accumulation of inositol-1-phosphate in COS-7 cells expressing recombinant human AT₁ (IC₅₀ = 2.6 nM). It reduces the maximal contractile response induced by angiotensin II in isolated rabbit aortic strips (pD₂ = 9.9). Azilsartan (100 ng/kg, i.v.) inhibits the angiotensin II-induced pressor response in conscious normotensive rats.

化学的特性

White to Off-White Solid

使用

Azilsartan is an analgesic and antiinflammatory drugs containing angiotensin II antagonists.

定義

ChEBI: A benzimidazolecarboxylic acid that is benzimidazole-7-carboxylic acid substituted at position 2 by a methoxy group and at position 1 by a 2'-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl group. Used (as the prodrug, azilsartan medoxomil) f r treatment of hypertension.

臨床応用

Azilsartan is an orally active angiotensin II blocker which was approved and launched in Japan for the treatment of arterial hypertension in May 2012. Azilsartan, which is marketed under the trade name Azilva®, was discovered and developed by Takeda—the same firm which had developed and launched a prodrug of azilsartan (azilsartan kamedoxomil, Edarbi®) in 2010. Azilsartan exhibits higher potency and slower off-rate kinetics for type 1 angiotensin II receptors, which contributes to azilsartan’s comparatively improved blood pressure lowering effect.

アジルサルタン 上流と下流の製品情報

原材料

準備製品

アジルサルタン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	998	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Jiangsu Zhongbang Pharmaceutical Co., Ltd.	025-87151996	zbsales@chinaredsun.com	CHINA	32	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9206	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60

147403-03-0(アジルサルタン)キーワード:

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• 147403-03-0
• AZILSARTAN
• 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid Azilsartan
• 2-ethoxy -1- {[2'-(5-oxo-4,5-dihydro -1,2,4 -oxadiazol-3-yl) biphenyl-4-yl ] methyl} -1H –benzimi[d]dazole-7-carboxylic acid
• 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
• 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
• Tak 536
• Unii-F9nux55p23
• 2-ethoxy-3-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid
• Azilsartan 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl]benziMidazole-7-carboxylic acid
• 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-1H-benziMidazole-7-carboxylic Acid
• Azilsartan (TAK-536)
• AzilsartanMedoxoMilInterMediates-3
• 2. 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl]benziMidazole-7-carboxylic acid
• 2-Ethoxy-1-｛[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]Methyl ｝-1H-benzo -[d]iMidazole-7- carboxylic acid
• 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-
• Azilsartan metabolite MI D4
• Azilsartan metabolite MII-D4
• Azilsartan API
• AZATMint-E
• Azilsartan, ≥98% (HPLC)
• CS-865
• Azilsartan >
• 2-Ethoxy-1-[(2-5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl)Biphenyl-4-Yl] Methyl-1H-Benzimidazole-7-Carboxalic Biphenyl-4-Yl] Methyl-1H-Benzimidazole-7-Carboxalic Acid
• Azilsartan USP/EP/BP
• 1-[2’-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]-2-ethoxy-1-H-benzimidazole-7- carboxylic acid
• 2-Ethoxy-1-[(2-5-Oxo-4,5-Dihydro-1,2,4-Oxadiazol-3-Yl) Biphenyl-4-Yl] Methyl-1H-Benzimidazole-7-Carboxalic Acid
• Generic API Azilsartan
• 2-Ethoxy-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
• Azilsartan Acid
• Azilsartan Base
• アジルサルタン
• アジルサルタン (JAN)
• 1-[2′-(5-オキソ-4,5-ジヒドロ-1,2,4-オキサジアゾール-3-イル)-4-ビフェニリルメチル]-2-エトキシ-1H-ベンゾイミダゾール-7-カルボン酸
• 2-エトキシ-1-[[2′-(5-オキソ-4,5-ジヒドロ-1,2,4-オキサジアゾール-3-イル)-4-ビフェニリル]メチル]-1H-ベンゾイミダゾール-7-カルボン酸
• 1-[2′-(5-オキソ-4,5-ジヒドロ-1,2,4-オキサジアゾール-3-イル)ビフェニル-4-イルメチル]-2-エトキシ-1H-ベンゾイミダゾール-7-カルボン酸
• 2-エトキシ-1-{[2'-(5-オキソ-4,5-ジヒドロ-1,2,4-オキサジアゾール-3-イル)-[1,1'-ビフェニル]-4-イル]メチル}-1H-1,3-ベンゾジアゾール-7-カルボン酸
• 2-エトキシ-1-[[2′-(5-オキソ-4,5-ジヒドロ-1,2,4-オキサジアゾール-3-イル)ビフェニル-4-イル]メチル]-1H-ベンゾイミダゾール-7-カルボン酸
• アジルバ