4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene
4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene 物理性質
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- Soluble in DMSO
- 外見 :
- Solid
- 色:
- Light yellow to yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene 価格
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4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene 化学特性,用途語,生産方法
一般的な説明
SMPT is a heterobifunctional sulfhydryl- and amine-reactive cross-linker. SMPT is used often for conjugating a toxin molecule to a monoclonal antibody directed against a cell-surface antigen. These immunotoxins produced with SMPT are highly potent as the cleavable disulfide imparts increased cytotoxicity compared to conjugates without a cleavable bond, such as those produced with SPDP. Also, next to the pyridine-2-thione in the spacer arm are a benzene ring and a methyl group adjacent to a carbon that hinders the disulfide bond, allowing exceptional conjugate stability in vivo. SMPT has the added benefit of being more stable to hydrolysis in aqueous solutions than other NHS cross-linkers.
4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene 上流と下流の製品情報
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4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene 生産企業
Global( 28)Suppliers
- 112241-19-7
- 4-succinimidyloxycarbonyl-alpha-methyl-alpha(2-pyridyldithio)toluene
- Benzoic acid, 4-[1-(2-pyridinyldithio)ethyl]-, 2,5-dioxo-1-pyrrolidinyl ester
- 2,5-dioxopyrrolidin-1-yl 4-(1-(pyridin-2-yldisulfaneyl)ethyl)benzoate
- 2,5-Dioxopyrrolidin-1-yl 4-[1-(pyridin-2-yldisulfanyl)ethyl]benzoate
- 4-Succinimidyloxycarbonyl-α-Methyl-α-(2-Pyridyldithio)toluene