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(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid

化学構造式
180713-37-5
CAS番号.
180713-37-5
化学名:
别名:
英語名:
(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid
英語别名:
CD 3159;UVI 2112;LG 100754;LG100754 >=98% (HPLC);(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid;(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2,4,6-Octatrienoic acid;2,4,6-Octatrienoic acid, 3-methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-, (2E,4E,6Z)-
CBNumber:
CB22518831
化学式:
C26H36O3
分子量:
396.56
MOL File:
180713-37-5.mol

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid 物理性質

沸点 :
549.4±50.0 °C(Predicted)
比重(密度) :
1.003±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO：可溶10mg/mL、透明
酸解離定数(Pka):
4.74±0.33(Predicted)
外見 :
粉
色:
白からベージュ

安全性情報

WGK Germany  3

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3831
LG 100754 		180713-37-5 50mg ￥249000 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TOC3831
LG 100754 		180713-37-5 10mg ￥54000 2020-09-21 購入
Sigma-Aldrich Japan SML0771 ≥98% (HPLC)
LG100754 ≥98% (HPLC)		 180713-37-5 5mg ￥20400 2024-03-01 購入
Sigma-Aldrich Japan SML0771 ≥98% (HPLC)
LG100754 ≥98% (HPLC)		 180713-37-5 25mg ￥79100 2024-03-01 購入

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid 化学特性,用途語,生産方法

説明

LG 100754 is a ligand of retinoid X receptor (RXR) that modulates the activity of RXR dimers. It acts as an antagonist towards RXR homodimers but as an agonist of heterodimers consisting of RXR and retinoic acid receptor (RAR) or PPARs. LG 100754, at 1 μM, is a weak agonist of RXR-PPARγ but strongly enhances signaling through the heterodimer in response to PPARγ ligands, including rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 . Through this action, LG 100754 decreases glucose levels and relieves insulin resistance in mice.

使用

LG 100754 is a novel RXR:PPARγ agonist and decreases glucose levels in vivo. It can also be used in compositions comprising anti-androgen and anti-thyroid agents and kits for diagnosis and treatment of viral respiratory infection.

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid 上流と下流の製品情報

原材料

準備製品

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid 生産企業

Global( 35)Suppliers
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  • 180713-37-5
  • (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid
  • LG 100754
  • (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2,4,6-Octatrienoic acid
  • 2,4,6-Octatrienoic acid, 3-methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-, (2E,4E,6Z)-
  • UVI 2112
  • LG100754 >=98% (HPLC)
  • CD 3159
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