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6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

化学構造式
64232-83-3
CAS番号.
64232-83-3
化学名:
别名:
英語名:
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
英語别名:
L189;L 189;L189;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
CBNumber:
CB22518932
化学式:
C11H10N4OS
分子量:
246.29
MOL File:
64232-83-3.mol

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 物理性質

融点 :
250 °C (decomp)
比重(密度) :
1.45±0.1 g/cm3(Predicted)
貯蔵温度 :
Keep in dark place,Inert atmosphere,2-8°C
溶解性:
≥62.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
外見 :
solid
酸解離定数(Pka):
8.16±0.60(Predicted)

安全性情報

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC3561
L189 		64232-83-3 10mg ￥64000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC3561
L189 		64232-83-3 50mg ￥184000 2018-12-26 購入

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 化学特性,用途語,生産方法

説明

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC50s = 5, 9, and 5 μM, respectively). It blocks DNA binding (Ki = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

使用

L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 上流と下流の製品情報

原材料

準備製品

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone 生産企業

Global( 86)Suppliers
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  スペクトルデータ(1HNMR)

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone(64232-83-3)1HNMR
  • 64232-83-3
  • 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
  • L189
  • 4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
  • (E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol
  • 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
  • L 189;L189
  • 6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
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