6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

64232-83-3

CAS-Nr.: 64232-83-3

Englisch Name:: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone

Synonyma:: L189;L 189;L189;(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone;6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one;6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone;4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-

CBNumber:: CB22518932

Summenformel:: C11H10N4OS

Molgewicht:: 246.29

MOL-Datei:: 64232-83-3.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 87

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Eigenschaften

Schmelzpunkt:: 250 °C (decomp)

Dichte: 1.45±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Inert atmosphere,2-8°C

Löslichkeit: ≥62.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Aggregatzustand: solid

pka: 8.16±0.60(Predicted)

Farbe: Light yellow to yellow

Sicherheit

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

L189 is a competitive inhibitor of DNA ligases I, III, and IV (IC₅₀s = 5, 9, and 5 μM, respectively). It blocks DNA binding (K_i = 5 μM for DNA ligase I), increasing the cytotoxicity of DNA-damaging agents, including ionizing radiation. L189 preferentially inhibits the interaction of the ligase with damaged DNA, inhibiting base excision repair and non-homologous end-joining.

Verwenden

L189 has been shown to inhibit DNA ligases I, III, and IV and may have potential use in the development of anticancer agents.

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 87)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69

6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
L189
4(1H)-PyriMidinone, 6-aMino-2,3-dihydro-5-[(phenylMethylene)aMino]-2-thioxo-
(E)-6-amino-5-(benzylideneamino)-2-mercaptopyrimidin-4-ol
6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-thioxo-4(1H)-pyrimidinone
L 189;L189
6-Amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
64232-83-3