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[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate

化学構造式
1469284-79-4
CAS番号.
1469284-79-4
化学名:
别名:
英語名:
[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
英語别名:
PF-06424439;PF-06424439 >=98% (HPLC);PF-06424439 methanesulfonate;[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate;(R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate;acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439
CBNumber:
CB22750426
化学式:
C23H30ClN7O4S
分子量:
536.0468
MOL File:
1469284-79-4.mol
MSDS File:
SDS

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate 物理性質

貯蔵温度 :
room temp
溶解性:
H2O: 可溶10mg/mL、透明
外見 :
粉
色:
白から薄茶色

安全性情報

WGK Germany  3

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan PZ0233 ≥98% (HPLC)
PF-06424439 ≥98% (HPLC)		 1469284-79-4 5mg ￥21300 2024-03-01 購入
Sigma-Aldrich Japan PZ0233 ≥98% (HPLC)
PF-06424439 ≥98% (HPLC)		 1469284-79-4 25mg ￥80100 2024-03-01 購入

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate 化学特性,用途語,生産方法

説明

PF-06424439 is an orally bioavailable inhibitor of diacylglycerol acyltransferase 2 (DGAT-2; IC50 = 14 nM). It is selective for DGAT-2 over the related acyltransferases DGAT-1, MGAT-2, and MGAT-3 (IC50s = >50 μM). PF-06424439 (0.1-10 mg/kg) reduces plasma triglyceride levels in sucrose-fed rats in a dose-dependent manner. It also reduces plasma levels of cholesterol and triglycerides as well as hepatic triglycerides in LDL receptor knockout mice fed a high-fat, high-cholesterol diet when administered at a dose of 60 mg/kg per day.

使用

PF-06424439 has been used as a diacylglycerol acyltransferase 2 (DGAT2)?inhibitor:
  • to study its effects on cell mortality and lipid synthesis in epithelial colon cells and colorectal cancer stem cells
  • to study its effects on HeLa cells
  • to study its inhibitory effects on neutral lipid synthesis in HT-1080 cells

Biochem/physiol Actions

PF-06424439 is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate 上流と下流の製品情報

原材料

準備製品

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate 生産企業

Global( 25)Suppliers
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1469284-79-4()キーワード:

ブレポシチニブ 3-(4-モルホリノ-7H-ピロロ[2,3-d]ピリミジン-5-イル)ベンゾニトリル 1,2-[(3R)-3-メチル-5-オキソ-1,4-ジアザペンタン-1,5-ジイル]-7-(2-メチル-5-ピリジル)チエノ[3,2-f]キノリン ニロガセスタット 6-[[5-(トリフルオロメチル)-4-[[3-(メチルスルホニル)ベンジル]アミノ]-2-ピリミジニル]アミノ]-3,4-ジヒドロキノリン-2(1H)-オン 7-[(2-メチルイミダゾ[2,1-b]チアゾール-6-イル)アセチル]-2-[5-(6-メチルピリミジン-4-イル)-2,3-ジヒドロ-1H-インデン-1-イル]-2,7-ジアザスピロ[3.5]ノナン ジェダトリシブ 2-アミノ-4-メチル-6-(6-メトキシピリジン-3-イル)-8-[4β-(2-ヒドロキシエチルオキシ)シクロヘキサン-1α-イル]ピリド[2,3-d]ピリミジン-7(8H)-オン PF477736
  • 1469284-79-4
  • [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate
  • PF-06424439 >=98% (HPLC)
  • PF-06424439 methanesulfonate
  • PF-06424439
  • acyl-CoA:cholesterol acyltransferase,Inhibitor,Acyltransferase,mono- acylglycerol acyltransferase,PF-06424439,PF 06424439 methanesulfonate,inhibit,Diacylglycerol acyltransferase,PF06424439,Diglyceride acyltransferase,PF06424439 methanesulfonate,PF 06424439
  • (R)-(1-(2-(1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl)-1H-imidazo[4,5-b]pyridin-5-yl)piperidin-3-yl)(pyrrolidin-1-yl)methanone methanesulfonate
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