4-フェニル酪酸
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAA18115 |
4-フェニル酪酸, 99%
4-Phenylbutyric acid, 99% |
1821-12-1 |
25g |
￥15350 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01AFAA18115 |
4-フェニル酪酸, 99%
4-Phenylbutyric acid, 99% |
1821-12-1 |
100g |
￥44880 |
2024-03-01 |
購入 |
|
東京化成工業
|
P0643 |
4-フェニル酪酸 >98.0%(GC)(T)
4-Phenylbutyric Acid
>98.0%(GC)(T) |
1821-12-1 |
25g |
￥7500 |
2024-03-01 |
購入 |
|
東京化成工業
|
P0643 |
4-フェニル酪酸 >98.0%(GC)(T)
4-Phenylbutyric Acid
>98.0%(GC)(T) |
1821-12-1 |
250g |
￥41000 |
2024-03-01 |
購入 |
|
関東化学株式会社(KANTO)
|
13038-3A |
４‐フェニル酪酸 99%
4‐Phenylbutyric acid 99% |
1821-12-1 |
100g |
￥30030 |
2024-07-01 |
購入 |
4-フェニル酪酸 化学特性,用途語,生産方法
外観
白色～うすい褐色, 結晶～結晶性粉末又は塊
溶解性
エタノール及びアセトンに溶けやすく、水に溶けにくい。アルコール、エーテルに易溶。
化学的特性
4-Phenylbutyric acid is white to slightly yellowish crystalline powder. It is slightly soluble in chloroform and methanol. Its solubility in water is 5.3 g/l (at 40 °C).
製造方法
4-phenylbutyric acid is obtained by the reaction of benzene with butyrolactone in the presence of aluminum chloride, followed by neutralization with base.
Synthesis of 4-phenylbutyric acid
主な応用
4-Phenylbutyric acid (4-PBA) is used in the treatment of urea cycle disorders under the trade name Buphenyl. 4-PBA has been used as a selective inhibitor of endoplasmic reticulum stress (ERS).
4-Phenylbutyric acid is used as organic intermediates. It can also be used as a reactant in the synthesis of:
1-Tetralone using Lewis acid catalyst.
4,N-diphenylbutyramide.
定義
4-Phenylbutyric acid is a monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apopto is in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
一般的な説明
4-Phenylbutyric acid (4-PBA) is a small-molecular-weight fatty acid with a terminal aromatic group, and its sodium salt (sodium 4-phenyl butyrate) has been used for the treatment of urea cycle disorders. This molecule is also used for the treatment of sickle cell diseases and thalassemia owing to its ability to activate β-globin transcription. Moreover, 4-PBA is employed as an orally bioavailable agent for the treatment of spinal muscular atrophy (SMA) and tumors.
Neuroprotective Effects of 4-phenylbutyric Acid and Its Derivatives: Possible Therapeutics for Neurodegenerative Diseases
純化方法
Crystallise the acid from pet ether (b 40-60o). [Beilstein 9 IV 1811.]
4-フェニル酪酸 上流と下流の製品情報
原材料
準備製品
4-フェニル酪酸 生産企業
Global( 471)Suppliers
4-フェニル酪酸 スペクトルデータ(1HNMR、13CNMR、IR1、IR2、MS、Raman)
1821-12-1(4-フェニル酪酸)キーワード:
- 1821-12-1
- GAMMA-PHENYL-N-BUTYRIC ACID
- GAMA-PHENYLBUTYRIC ACID
- AKOS BBS-00003749
- 4-PHENYL-N-BUTYRIC ACID
- 4-PHENYLBUTYRIC ACID
- benzenebutanoicacid
- Benzenebutyric acid
- Butyric acid, 4-phenyl-
- gamma-Phenylbutyric acid
- omega-Phenylbutanoic acid
- 4-PHENYBUTYTIC ACID
- 4-PhenylButyricAcid99%
- 4- Phenyl Butyric Acid 99%
- 4-Phenylbutyricacid98%
- 4-Phenylbutyric acid 4-phenylbutanoic acid
- 4-PHENYLBUTYRIC ACID pure
- TIMTEC-BB SBB008452
- RARECHEM AL BO 0178
- 4-Phenylbutanoic acid 98%
- 4-Phenylbutyric acid≥ 99% (Assay)
- 4-benzene acid
- NSC 295
- γ-Phenylbutanoic Acid
- 4-Phenylbutyric Acid, 97+%
- 4-PhenylbutyricAcid>
- 4-Phenylbutyric acid (4-PBA)
- p-Phenylbutyric acid
- 4-Phenyl butyroic acid
- Cinacalcet Impurity 6 (4-Phenylbutyric Acid)
- 4-PHENYLBUTYRIC ACID Extra Pure
- 4-フェニル酪酸
- 4-フェニルブタン酸
- ベンゼン酪酸
- 4-(フェニル)ブタン酸
- 4-(フェニル)酪酸
- ベンゼンブタン酸
- 4‐フェニル酪酸
- 4-フェニル酪酸, 99%