P1 化学特性,用途語,生産方法
使用
P1 is a starting material and useful building block of various pharmaceuticals.
酵素阻害剤
This cell-permeable PDI inhibitor (FW = 583.70 g/mol; CAS 1461648-55- 4; Soluble to 100 mM in DMSO; N-[(1,1-dimethylethoxy)carbonyl]-Lphenylalanyl-O-(ethenyl-sulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide) targets protein disulfide isomerase (IC50 = 1.7 μM), an enzyme that assists in the folding of cellular proteins within the endoplasmic reticulum of mammalian cells. P1 reduces the proliferation of numerous cancer cell lines, with nominal GI50 values of ~4 μM. PDI binds to the axonal microtubuleassociated protein known as Tau, mainly through its thioredoxin-like catalytic domain, by forming a one-to-one complex that prevents Tau misfolding.
P1 上流と下流の製品情報
原材料
準備製品