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P1

P1 구조식 이미지

카스 번호:: 1461648-55-4

상품명:: P1

동의어(영문):: PDIINP1;PDI-IN-P1;PDI IN P1;PDI-inhibitor-P1;PDI inhibitor P1;PDI IN P1,PDI-IN-P-1;N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide;L-Tyrosinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-O-(ethenylsulfonyl)-N-4-pentyn-1-yl-

CBNumber:: CB24866440

분자식:: C30H37N3O7S

포뮬러 무게:: 583.7

MOL 파일:: 1461648-55-4.mol

속성

안전

용도

공급 업체 8

P1 속성

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

안전

P1 C화학적 특성, 용도, 생산

용도

P1 is a starting material and useful building block of various pharmaceuticals.

효소 저해제

This cell-permeable PDI inhibitor (FW = 583.70 g/mol; CAS 1461648-55- 4; Soluble to 100 mM in DMSO; N-[(1,1-dimethylethoxy)carbonyl]-Lphenylalanyl-O-(ethenyl-sulfonyl)-N-4-pentyn-1-yl-L-tyrosinamide) targets protein disulfide isomerase (IC50 = 1.7 μM), an enzyme that assists in the folding of cellular proteins within the endoplasmic reticulum of mammalian cells. P1 reduces the proliferation of numerous cancer cell lines, with nominal GI50 values of ～4 μM. PDI binds to the axonal microtubuleassociated protein known as Tau, mainly through its thioredoxin-like catalytic domain, by forming a one-to-one complex that prevents Tau misfolding.

P1 준비 용품 및 원자재

원자재

준비 용품

P1 공급 업체

글로벌( 8)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
BOC Sciences	--	info@bocsci.com	USA	0	65
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4608	58