イカルガマイシン

イカルガマイシン 価格 もっと(5)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01LKTI4000	イカルガマイシン Ikarugamycin	36531-78-9	1mg	￥86900	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTI4000	イカルガマイシン Ikarugamycin	36531-78-9	500μg	￥39300	2023-06-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTI4000	イカルガマイシン Ikarugamycin	36531-78-9	0.5mg	￥33100	2021-03-23	購入
Sigma-Aldrich Japan	SML0188	≥98% (HPLC), from Streptomyces sp. Ikarugamycin ≥98% (HPLC), from Streptomyces sp.	36531-78-9	500ug	￥49800	2018-12-25	購入
富士フイルム和光純薬株式会社(wako)	W01LKTI4000	イカルガマイシン Ikarugamycin	36531-78-9	5mg	￥216100	2023-06-01	購入

イカルガマイシン 化学特性,用途語,生産方法

説明

Ikarugamycin is a macrocyclic antibiotic first isolated from Streptomyces sp. that demonstrates potent antiprotozoal activity. It exhibits cytotoxic effects in cancer cell lines, inhibiting cell proliferation (IC₅₀ = 221.3 nM in HL-60 cells) through genotoxicity and by inducing apoptosis and activation of caspases. It also was shown to significantly inhibit oxidized low-density lipoprotein-induced accumulation of cholesteryl esters in macrophages at 1-4 μM. Additionally, ikarugamycin is used to inhibit clathrin-coated pit-mediated endocytosis.

使用

Ikarugamycin is an unusual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes, with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrates selective Gram positive antibacterial activity, and anti-ucler activity possibly via inhibition of H. pylori. In addition, ikarugamycin inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and Nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful agent for studying the process of endocytosis.

定義

ChEBI: A polyketide macrolactam containing a tetramic acid (2,4-pyrrolidine-2,4-dione) ring system. It is isolated from Streptomyces as an antibitoic with antiprotozoal and cytotoxic activities.

イカルガマイシン 上流と下流の製品情報

原材料

準備製品

イカルガマイシン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32079	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15354	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19741	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-18791163155 +86-13119157289	13119157289@163.com	China	2971	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58

36531-78-9(イカルガマイシン)キーワード:

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• 36531-78-9
• TU-6239 C3
• IKARUGAMYCIN
• 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione
• 3-Ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-
• 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione, 3-ethyl-2,3,3a,5a,5b,6,10,11,12,13,14,15,20a,21,21a,21b-hexadecahydro-22-hydroxy-2-methyl-, (2R,3R,3aS,5aR,5bS,7Z,14S,19E,20aS,21aR,21bR)-
• WSUGGLXIPUHOSG-XSYQVIBFSA-N
• turbinomycin
• イカルガマイシン
• (5S,7R,8R,10R,11R,12S,15R,16S,25S)-11-エチル-28-ヒドロキシ-10-メチル-21,26-ジアザペンタシクロ[23.2.1.05,16.07,15.08,12]オクタコサ-1(28),3,13,18-テトラエン-2,20,27-トリオン