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d-フェンフルラミン·塩酸塩

d-フェンフルラミン·塩酸塩 化学構造式
3239-45-0
CAS番号.
3239-45-0
化学名:
d-フェンフルラミン·塩酸塩
别名:
(S)-N-エチル-α-メチル-3-(トリフルオロメチル)ベンゼンエタンアミン·塩酸塩;d-フェンフルラミン·塩酸塩;d-フェンフルラミン塩酸塩;(+)-フェンフルラミン塩酸塩;デクスフェンフルラミン塩酸塩;d-フェンフルラミン・塩酸塩;(S)-N-エチル-α-メチル-3-(トリフルオロメチル)ベンゼンエタンアミン・塩酸塩
英語名:
(+)-Fenfluramine hydrochloride
英語别名:
Glypolix;Isomeride;S5614 HCl;S-Fenfluramine HCl;(+)-Fenfluramine Hydrochlorid;Dexfenfluramine hydrochloride;(+)-Fenfluramine hydrochloride;(S)-(+)-Fenfluramine Hydrochloride;S(+)-FENFLURAMINE HYDROCHLORIDE SEROTONI N UPTAKE INHI;(S)-(+)-Fenfluramine Hydrochloride (1.0mg/ml in Acetonitrile)
CBNumber:
CB2879459
化学式:
C12H17ClF3N
分子量:
267.7182896
MOL File:
3239-45-0.mol

d-フェンフルラミン·塩酸塩 物理性質

融点 :
159-163°C
貯蔵温度 :
Desiccate at RT
溶解性:
H2O: 可溶性10mg/mL
外見 :
粉
色:
ホワイトからオフホワイト

安全性情報

主な危険性  T
Rフレーズ  23/24/25
Sフレーズ  22-36/37/39-45
RIDADR  UN 2811
WGK Germany  3
RTECS 番号 SH6824000
国連危険物分類  6.1(b)
容器等級  III

d-フェンフルラミン·塩酸塩 化学特性,用途語,生産方法

効能

食欲抑制薬 (全身性), セロトニン再取り込み阻害薬

説明

Redux, having been already launched in Europe, was marketed in Canada and the US for obesity. The (+)-isomer of fenfluramine is obtained by resolution using d-camphoric acid and ultimate conversion to the HCl salt. The levo-isomer has significant effects on dopaminerigic neurotransmission, while the dextro-isomer has a greater anorectic effect because it is more selective on serotonin as a 5-HT agonist with no dopaminergic or noradenergic activity. Redux inhibits the presynaptic release of serotonin, is a reuptake inhibitor, a 5-HT1B, receptor agonist, and a postsynaptic 5-HT2C receptor agonist . A dietary reduction in fat intake was thought to proceed via a CCK A-type receptor agonist activity. Due to the side effects of primary pulmonary hypertension, brain serotonin neurotoxicity and valvular heart disease, Redux was withdrawn world wide.

化学的特性

White Crystalline Powder

使用

Controlled substance. Anorexic

定義

ChEBI: The hydrochloride salt of (S)-fenfluramine. It stimulates the release of serotonin and selectively inhibits its reuptake, but unlike the racemate it does not possess catecholamine agonist activity. It was formerly given by mouth in the tre tment of obesity, but, like the racemate, was withdrawn wolrdwide following reports of valvular heart defects.

生物活性

Indirectly agonizes serotonin receptors via inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent; decreases growth hormone, insulin, leptin, fat mass, lean mass and increases ghrelin in diet-switched diet-induced obese mice.

d-フェンフルラミン·塩酸塩 上流と下流の製品情報

原材料

準備製品

3239-45-0(d-フェンフルラミン·塩酸塩)キーワード:

フェンフルラミン 鉄－デキストラン錯体 3-(トリフルオロメチル)フェネチルアミン 2-フェニルエチルアミン (αR)-3-トリフルオロメチル-N-エチル-α-メチルベンゼンエタンアミン (±)-フェンフルラミン塩酸塩標準品 デクスフェンフルラミン
  • 3239-45-0
  • (S)-N-ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochloride
  • Dexfenfluramine hydrochloride
  • Dexfenfluramine hydrochloride, (+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride
  • ethyl-[(1S)-1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amine hydrochloride
  • (S)-(+)-Fenfluramine Hydrochloride
  • (S)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanaminehydrochloride
  • (aS)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine Hydrochloride
  • S-Fenfluramine HCl
  • S(+)-FENFLURAMINE HYDROCHLORIDE SEROTONI N UPTAKE INHI
  • (+)-Fenfluramine Hydrochlorid
  • (+)-N-Ethyl-a-methyl-m-(trifluoromethyl)phenethylamine Hydrochloride
  • (aS)-N-Ethyl-a-methyl-3-(trifluoromethyl)benzeneethanamine Hydrochloride
  • Glypolix
  • Isomeride
  • S5614 HCl
  • (+)-Fenfluramine hydrochloride
  • (S)-N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine hydrochloride
  • (S)-(+)-Fenfluramine Hydrochloride (1.0mg/ml in Acetonitrile)
  • (S)-N-エチル-α-メチル-3-(トリフルオロメチル)ベンゼンエタンアミン·塩酸塩
  • d-フェンフルラミン·塩酸塩
  • d-フェンフルラミン塩酸塩
  • (+)-フェンフルラミン塩酸塩
  • デクスフェンフルラミン塩酸塩
  • d-フェンフルラミン・塩酸塩
  • (S)-N-エチル-α-メチル-3-(トリフルオロメチル)ベンゼンエタンアミン・塩酸塩
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