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セニカポク

セニカポク 化学構造式
289656-45-7
CAS番号.
289656-45-7
化学名:
セニカポク
别名:
セニカポク
英語名:
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
英語别名:
Senicapoc;ICA 17043;Senicapoc (ICA17043);ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
CBNumber:
CB31261049
化学式:
C20H15F2NO
分子量:
323.34
MOL File:
289656-45-7.mol

セニカポク 物理性質

融点 :
180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
沸点 :
460.7±45.0 °C(Predicted)
比重(密度) :
1.250±0.06 g/cm3(Predicted)
貯蔵温度 :
Sealed in dry,Store in freezer, under -20°C
溶解性:
DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
外見 :
Powder
酸解離定数(Pka):
15.41±0.50(Predicted)
色:
White to yellow

安全性情報

セニカポク 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MAS094238
2,2-Bis(4-fluorophenyl)-2-phenylacetamide 		289656-45-7 250mg ￥132900 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01MAS094238
2,2-Bis(4-fluorophenyl)-2-phenylacetamide 		289656-45-7 1g ￥398800 2024-03-01 購入

セニカポク 化学特性,用途語,生産方法

効能

鎌形赤血球貧血治療薬, カリウム中間体/小コンダクタンスカルシウム活性化チャネル拮抗薬

説明

Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.

使用

Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.

セニカポク 上流と下流の製品情報

原材料

準備製品

セニカポク 生産企業

Global( 81)Suppliers
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セニカポク  スペクトルデータ(1HNMR)

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide(289656-45-7)1HNMR

289656-45-7(セニカポク)キーワード:

2-フルオロフェニルシクロペンチルケトン 2,6-ジフルオロベンズアミド セニカポク
  • 289656-45-7
  • 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
  • Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-
  • 4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
  • 4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide
  • ICA 17043
  • Senicapoc
  • ICA-17043;ICA 17043;ICA17043
  • Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-
  • Senicapoc (ICA17043)
  • セニカポク
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