4-bromobutyl nitrate
4-bromobutyl nitrate 物理性質
- 沸点 :
- 220.0±23.0 °C(Predicted)
- 比重(密度) :
- 1.560±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Refrigerator, under inert atmosphere
- 溶解性:
- クロロホルム（微量）、メタノール（微量）
- 外見 :
- 油
- 色:
- ペールイエロー
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
4-bromobutyl nitrate 価格
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4-bromobutyl nitrate 化学特性,用途語,生産方法
使用
4-bromobutyl nitrate is an intermediate in synthesizing Latanoprostene Bunod (L177335). It is a derivative of Latanoprost and is used in the treatment of interocular pressure.
製造方法
4-Bromobutyl nitrate is a thermally unstable oily liquid, which is used to obtain nitrooxyalkyl esters of pharmacologically active carboxylic acids (WO 04/020384, WO 04/020385). 4-Bromobutyl nitrate not dissolved in solvents is added to the solution / suspension of pharmacologically active carboxylic acids such as naproxen, ferulic acid, etc. 4-Bromobutyl nitrate is obtained by nitration with a sulfonitizing mixture of 4-bromo-1-hydroxybutane (Chem. Pharm. Bull., 1993, 41, p. 1040). The reaction is carried out by adding 4-bromo-1-hydroxybutane to the crude sulphonating mixture in the absence of solvents or diluents. The reaction is limited to a laboratory scale since the method is potentially explosive due to a sudden increase in temperature and gas production.
https://patents.google.com/patent/RU2388746C2/en
4-bromobutyl nitrate 上流と下流の製品情報
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4-bromobutyl nitrate 生産企業
Global( 10)Suppliers
- 146563-40-8
- 4-bromobutyl nitrate
- SKL119
- 1-Butanol, 4-bromo-, 1-nitrate
- 4-Bromo-1-butanol 1-Nitrate
- 4-(nitrooxy)butyl bromide