Brinzolamide-d5 化学特性,用途語,生産方法
説明
Brinzolamide-d
5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC
50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC
50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.
化学的特性
Crystalline Solid
使用
Carbonic anhydrase inhibitor. Antiglaucoma agent.
Brinzolamide-d5 上流と下流の製品情報
原材料
準備製品