Brinzolamide-d5

Brinzolamide-d5 Struktur
1217651-02-9
CAS-Nr.
1217651-02-9
Englisch Name:
Brinzolamide-d5
Synonyma:
Brinzolamide-d5;[2H5]-Brinzolamide
CBNumber:
CB32507883
Summenformel:
C12H21N3O5S3
Molgewicht:
383.5
MOL-Datei:
1217651-02-9.mol

Brinzolamide-d5 Eigenschaften

storage temp. 
Refrigerator
Löslichkeit
Ethanol
Aggregatzustand
Solid
Farbe
Crystalline

Sicherheit

Brinzolamide-d5 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Brinzolamide-d5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.

Chemische Eigenschaften

Crystalline Solid

Verwenden

Carbonic anhydrase inhibitor. Antiglaucoma agent.

Brinzolamide-d5 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Brinzolamide-d5 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 20)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32344 50
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9708 58
Hubei Yangxin Medical Technology Co., Ltd. 15374522761
3003392093@qq.com China 8255 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266
marketing1@energy-chemical.com China 44843 58
Shanghai isotope chemical co.,ltd 021-021-51600108 13062666369
sales@chinaisotope.com China 4274 58
Nanjing Shizhou Biology Technology Co.,Ltd 17301488900
judy.xia@synzest.com China 12584 58
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