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STAT5 Inhibitor

化学構造式
285986-31-4
CAS番号.
285986-31-4
化学名:
别名:
英語名:
STAT5 Inhibitor
英語别名:
MDK6314;CS-2509;STAT5-IN-1;STAT5 Inhibitor;STAT5 Inhibitor 1;Stat5 Inhibitor(STAT5-IN-1);N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide;STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT;N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide;(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
CBNumber:
CB32515923
化学式:
C16H11N3O3
分子量:
293.28
MOL File:
285986-31-4.mol

STAT5 Inhibitor 物理性質

融点 :
214-216 °C
比重(密度) :
1.33±0.1 g/cm3(Predicted)
貯蔵温度 :
2-8°C(protect from light)
溶解性:
≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
外見 :
crystalline solid
酸解離定数(Pka):
10.44±0.46(Predicted)
色:
White to light yellow

安全性情報

STAT5 Inhibitor 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

STAT5 Inhibitor 化学特性,用途語,生産方法

説明

Signal Transducers and Activators of Transcriptions (STATs) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. STAT5, which consists of two isoforms STAT5α and STAT5β, is known to be overactive in several kinds of leukemias and various solid tumors. STAT5 Inhibitor is a cell-permeable, nonpetidic nicotinoyl hydrazone that suppresses STAT5 by targeting its SH2 domain (IC50 = 47 μM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound exhibits reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC50 > 500 μM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts.

使用

2-?[(4-?Oxo-?4H-?1-?benzopyran-?3-?yl)?methylene]?hydrazide-3-?pyridinecarboxylic Acid is a selective inhibitor of STAT5.

定義

ChEBI: A carbohydrazide that is nicotinohydrazide in which the terminal nitrogen has undergone formal condensation with the aldehyde group of 4-oxo-4H-chromene-3-carbaldehyde. It is an inhibitor of STAT5 (Signal Transducer and Activator of Tran cription 5) protein.

STAT5 Inhibitor 上流と下流の製品情報

原材料

準備製品

STAT5 Inhibitor 生産企業

Global( 82)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
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InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 4692 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58

  スペクトルデータ(1HNMR)

STAT5 Inhibitor(285986-31-4)1HNMR
  • 285986-31-4
  • STAT5-IN-1
  • N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
  • STAT5 Inhibitor
  • CS-2509
  • STAT5 Inhibitor 1
  • (E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
  • MDK6314
  • 3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide
  • STAT-5-IN-1,STAT5IN1,inhibit,STAT5 IN 1,Inhibitor,STAT
  • Stat5 Inhibitor(STAT5-IN-1)
  • N'3-[(4-oxo-4H-chromen-3-yl)methylidene]pyridine-3-carbohydrazide
  • N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
  • 3-{[(1E)-2-(pyridin-3-ylcarbonyl)diazanylidene]methyl}-4H-chromen-4-one
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