L 656748

 化学構造式
121124-29-6
CAS番号.
121124-29-6
化学名:
别名:
英語名:
L 656748
英語别名:
L 656748;EMaMectin B1a;Unii-IX4GP7848F;Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
CBNumber:
CB32703722
化学式:
C49H75NO13
分子量:
886.12
MOL File:
121124-29-6.mol

L 656748 物理性質

沸点 :
935.0±65.0 °C(Predicted)
比重(密度) :
1.21±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C, protect from light
溶解性:
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
外見 :
A solid
酸解離定数(Pka):
12.42±0.70(Predicted)
安定性::
Light Sensitive

安全性情報

L 656748 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

L 656748 化学特性,用途語,生産方法

説明

Emamectin B1a is a semisynthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically.

使用

Emamectin B1a is a semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin. Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells.

L 656748 上流と下流の製品情報

原材料

準備製品


L 656748 生産企業

Global( 20)Suppliers
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BOC Sciences
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
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ShangHai Anpel Co, Ltd. 18501792038; 18501792038
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Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829
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Energy Chemical 021-58432009 400-005-6266
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Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
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TargetMol Chemicals Inc. 15002134094
marketing@targetmol.com China 24246 58

121124-29-6()キーワード:


  • 121124-29-6
  • EMaMectin B1a
  • L 656748
  • Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
  • Unii-IX4GP7848F
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