L 656748

L 656748 Struktur
121124-29-6
CAS-Nr.
121124-29-6
Englisch Name:
L 656748
Synonyma:
L 656748;EMaMectin B1a;Unii-IX4GP7848F;Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
CBNumber:
CB32703722
Summenformel:
C49H75NO13
Molgewicht:
886.12
MOL-Datei:
121124-29-6.mol

L 656748 Eigenschaften

Siedepunkt:
935.0±65.0 °C(Predicted)
Dichte
1.21±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C, protect from light
Löslichkeit
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
Aggregatzustand
A solid
pka
12.42±0.70(Predicted)
Stabilität:
Light Sensitive

Sicherheit

L 656748 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Emamectin B1a is a semisynthetic derivative of avermectin B1a . It binds to GABAA receptors (Ki = 17.6 nM in rat brain membranes), including those containing β1, β2, or β3 subunits (IC50s = 57, 210, and 49.8 nM for α1β1γ2, α1β2γ2, and α1β3γ2 subunits, respectively), and potentiates the GABA response. Emamectin B1a also binds to and inhibits glycine receptors (IC50 = 218 nM in rat spinal cord). Emamectin B1a induces mortality in 90% of S. exigua larvae in a diet incorporation assay at a dose of 1.067 ng/ml, which is approximately 1,500-fold more toxic than avermectin B1. It is effective against neonate S. eridania larvae in a foliage spray bioassay and when applied topically.

Verwenden

Emamectin B1a is a semi-synthetic 4”-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4”-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin. Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells.

L 656748 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


L 656748 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 20)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19743 58
Lynnchem 86-(0)29-85992781 17792393971
info@lynnchem.com China 4587 58
Novachemistry 44-20819178-90 02081917890
info@novachemistry.com United Kingdom 4381 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684
sales@rrkchem.com China 56057 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11289 58
ShangHai Anpel Co, Ltd. 18501792038; 18501792038
shanpel@anpel.com.cn China 9614 58
Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829
sales@mitachieve.com China 8864 58
Energy Chemical 021-58432009 400-005-6266
marketing1@energy-chemical.com China 44843 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 8740 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.com China 24246 58

  • EMaMectin B1a
  • L 656748
  • Avermectin A1a, 5-O-demethyl-4''-deoxy-4''-(methylamino)-, (4''R)-
  • Unii-IX4GP7848F
  • 121124-29-6
Copyright 2019 © ChemicalBook. All rights reserved