ケトシン

ケトシン 価格 もっと(5)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01CHDASB-00003373	ケトシン Chaetocin	28097-03-2	1mg	￥67800	2020-09-21	購入
富士フイルム和光純薬株式会社(wako)	W01CHDASB-00003373	ケトシン Chaetocin	28097-03-2	5mg	￥237400	2020-09-21	購入
Sigma-Aldrich Japan	C9492	ケトシン from Chaetomium minutum ≥95% (HPLC) Chaetocin from Chaetomium minutum ≥95% (HPLC)	28097-03-2	1mg	￥93400	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC4504	Chaetocin	28097-03-2	1mg	￥89000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01CHDASB-00003373	ケトシン Chaetocin	28097-03-2	10mg	￥356700	2020-09-21	購入

ケトシン 化学特性,用途語,生産方法

説明

Chaetocin (28097-69-1) is an antimicrobial fungal metabolite. It was found to be a specific inhibitor of the lysine-specific histone methyltransferase SU(VAR)3-9 (IC50 = 0.6 mM) of Drosophila melanogaster and of its human ortholog (IC50 = 0.8 mM). It acts as a competitive inhibitor for S-adenosylmethionine. The specificity of chaetocin for SU(VAR)3-9 makes this compound an excellent tool for the study of heterochromatin-mediated gene repression. Chaetocin has an antimyeloma activity which has been linked to induction of oxidative stress and subsequent apoptosis.

化学的特性

Chaetocin is supplied as a crystalline solid. A stock solution may be made by dissolving the chaetocin in the solvent of choice, which should be purged with an inert gas. Chaetocin is soluble in organic solvents such as DMSO. The solubility of chaetocin in DMSO is approximately 25 mg/ml.

使用

Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumour agent. Chaetocin is an inhibitor of lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress.

主な応用

Chaetocin is a natural metabolite isolated from Chaetomium minutum. It is a nonspecific inhbitor of histone lysine methyltransferases which are important epigenetic enzymes . Induces apoptosis in myeloma cell lines and exhibits antiproliferative activity in mammals. Chaetocin from Chaetomium minutum has been used to determine its effects on sensitization of various cells. It has also been used to determine the biological functions of OS-induced heterochromatin formation.

一般的な説明

Chaetocin is a fungal metabolite with antimicrobial and cytostatic activity. It belongs to the 3,6-epidithio-diketopiperazines class of which gliotoxin, sporidesmin, aranotin, oryzachloride, verticillin A and the melinacidins are members. Chaetocin is a molecular dimer of two five-membered rings cis fused. Interestingly, the chirality of the 3,6-epidithiodioxopiperazine moiety in chaetocin is opposite to the chirality of gliotoxin, sporidesmin, aranotin, and oryzachloride. Unlike these compounds, chaetocin does not have an antiviral activity. This fungal toxin showed strong cytotoxicity against HeLa cells (IC50 = 0.05 mg/ml).

Biochem/physiol Actions

Chaetocin is a competitive inhibitor for S-adenosylmethionine. The specificity of chaetocin for SU(VAR)3-9 makes this compound an excellent tool for the study of heterochromatin-mediated gene repression.

ケトシン 上流と下流の製品情報

原材料

準備製品

ケトシン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29825	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	24330	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shaanxi LonierHerb Bio Technology Co Ltd	+86-86-+86-86-029-87551862 +8617702909819	sales006@ingredients-lonier.com	China	2605	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

28097-03-2(ケトシン)キーワード:

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• 28097-03-2
• chetocin
• CHAETOCIN FROM CHAETOMIUM MINUTUM
• CHAETOCIN(SH)
• (3S,3'S,5aR,5'aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-Octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone
• Chaetocin A
• [10b,10'b(11H,11'H)-Bi-3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone,2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-,(3S,3'S,5aR,5'aR,10bR,10'bR,11aS,11'aS)-
• HMTase Inhibitor II, Chaetocin
• (3S,3'S,6R,6'R,14R,14'R,16S,16'S)-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-2,2',3,3',6,6',7,7'-octahydro-1H,1'H-[14,14'-bi(3,11a-epidithiopyrazino[1',2':1,5]pyrrolo[2,3-b]indole)]-1,1',4,4'(15H,15'H)-tet
• Chaetocin, 98%, from fungus
• HMTase Inhibitor II, Chaetocin - CAS 28097-03-2 - Calbiochem
• Chaetocin, from fungus
• Chaetocin from Chaetomium minutum >=95% (HPLC)
• CHAETOCIN FROM CHAETOMIUM MINUTUM USP/EP/BP
• CHAETOCIN
• ケトシン
• (+)-カエトシン
• (1S,3R,11R,14S)-14-(ヒドロキシメチル)-3-[(1S,3R,11R,14S)-14-(ヒドロキシメチル)-18-メチル-13,17-ジオキソ-15,16-ジチア-10,12,18-トリアザペンタシクロ[12.2.2.01,12.03,11.04,9]オクタデカ-4,6,8-トリエン-3-イル]-18-メチル-15,16-ジチア-10,12,18-トリアザペンタシクロ[12.2.2.01,12.03,11.04,9]オクタデカ-4,6,8-トリエン-13,17-ジオン
• 2,2′-ジメチル-3,3′-ビス(ヒドロキシメチル)-10b,10b′-ビ[(3S,10bR)-5aα,6,10b,11-テトラヒドロ-3β,11aβ-ジチオ-2H-ピラジノ[1′,2′:1,5]ピロロ[2,3-b]インドール-1,4(3H,11aH)-ジオン]
• (+)-ケトシン
• カエトシン