クリソマイシンB
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- CAS番号.
- 83852-56-6
- 化学名:
- クリソマイシンB
- 别名:
- 英語名:
- CHRYSOMYCIN B
- 英語别名:
- B,ChrysoMycin;CHRYSOMYCIN B USP/EP/BP;ChrysoMycin M, VirenoMycin M, Albacarcin M;6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-;4-(6-Deoxy-3-C-methyl-beta-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one;6H-Benzo[d]naphtho[1,2-b]pyran-6-one,4-(6-deoxy-3-C-methyl-b-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl- (9CI)
- CBNumber:
- CB3503294
- 化学式:
- C27H28O9
- 分子量:
- 496.51
- MOL File:
- 83852-56-6.mol
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クリソマイシンB 物理性質
- 沸点 :
- 784.0±60.0 °C(Predicted)
- 比重(密度) :
- 1.410
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMF：可溶
- 酸解離定数(Pka):
- 8.59±0.20(Predicted)
- 外見 :
- 個体
- 色:
- Yellow to greenish
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01FLCM01375 |
クリソマイシンB
Chrysomycin B |
83852-56-6 |
1mg |
￥272500 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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C6491 |
≥98% (HPLC), solid
Chrysomycin B ≥98% (HPLC), solid |
83852-56-6 |
100μg |
￥54080 |
2021-03-23 |
購入 |
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Sigma-Aldrich Japan
|
C6491 |
クリソマイシンB ≥98% (HPLC), solid
Chrysomycin B ≥98% (HPLC), solid |
83852-56-6 |
100ug |
￥62800 |
2018-12-25 |
購入 |
クリソマイシンB 化学特性,用途語,生産方法
説明
Chrysomycin B is an antibiotic isolated from a strain of
Streptomyces. It differs from its analog chrysomycin A by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA. It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.
使用
Chrysomycin B is a minor analogue in a complex of C-glycoside antitumour actives isolated from Streptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent antitumour active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones.
クリソマイシンB 上流と下流の製品情報
原材料
準備製品
クリソマイシンB 生産企業
Global( 34)Suppliers
83852-56-6(クリソマイシンB)キーワード:
- 83852-56-6
- 6H-Benzo[d]naphtho[1,2-b]pyran-6-one,4-(6-deoxy-3-C-methyl-b-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl- (9CI)
- ChrysoMycin M, VirenoMycin M, Albacarcin M
- 4-(6-Deoxy-3-C-methyl-beta-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one
- B,ChrysoMycin
- 6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-
- CHRYSOMYCIN B USP/EP/BP