Tetraacetylphytosphingosine
Tetraacetylphytosphingosine 物理性質
- 融点 :
- 46 °C
- 沸点 :
- 594.3±50.0 °C(Predicted)
- 比重(密度) :
- 1.021±0.06 g/cm3(Predicted)
- 酸解離定数(Pka):
- 14.72±0.46(Predicted)
- InChIKey:
- SGTYQWGEVAMVKB-NXCFDTQHSA-N
- SMILES:
- C(N[C@@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)CCCCCCCCCCCCCC)(=O)C
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
Tetraacetylphytosphingosine 価格
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Tetraacetylphytosphingosine 化学特性,用途語,生産方法
説明
Tetraacetylphytosphingosine (TAPS) is a sphingolipid metabolite produced by Wickerhamomyces ciferrii (also known as Hansenula ciferrii). It exerts an inhibitory action on angiogenesis through inhibition of the mitogen-activated protein kinase (MAPK) pathway and intracellular calcium increase. Therefore, TAPS was suggested as a potential treatment for angiogenesis related disorders such as arthritis, cancer and psoriasis.
生物活性
Tetraacetylphytosphingosine was found to induce apoptosis in HaCaT human keratinocyte cells. In addition, it was demonstrated that TAPS synergistically increases UVB-induced apoptosis via caspase activation by regulating the level of pro-apoptotic Bax and anti-apoptotic Bcl-2 in HaCaT cells.
in vitro
Tetraacetylphytosphingosine (TAPS; 5 μM; 24 h) markedly decreases VEGF-induced chemotactic migration and capillary-like tube formation in HUVEC. It significantly inhibits VEGF-induced proteolytic enzyme production, including MMP-2, urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1). It also suppresses VEGF-induced phosphorylation of p42/44 extracellular signal-regulated kinase and c-JNK. In addition, Tetraacetylphytosphingosine abolished VEGF-induced intracellular calcium increase. In HaCaT cells, Tetraacetylphytosphingosine co-treatment synergistically increases the level of UVB-induced apoptosis via caspase activation by regulating pro-apoptotic Bax and anti-apoptotic Bcl-2 levels.
Tetraacetylphytosphingosine 上流と下流の製品情報
原材料
準備製品
Tetraacetylphytosphingosine 生産企業
Global( 21)Suppliers
- 13018-48-9
- Acetamide, N-[(1S,2S,3R)-2,3-bis(acetyloxy)-1-[(acetyloxy)methyl]heptadecyl]-
- Tetraacetylphytosphingosine >=98% (HPLC)
- Tetraacetylphytosphingosine >
- Tetraacetyl-D-ribo-Phytosphingosine
- TETRAACETYLPHYTOSPHINGOSINE