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Tetraacetylphytosphingosine

Tetraacetylphytosphingosine 구조식 이미지

카스 번호:: 13018-48-9

상품명:: Tetraacetylphytosphingosine

동의어(영문):: TETRAACETYLPHYTOSPHINGOSINE;Tetraacetylphytosphingosine >Tetraacetyl-D-ribo-Phytosphingosine;Tetraacetylphytosphingosine >=98% (HPLC);Acetamide, N-[(1S,2S,3R)-2,3-bis(acetyloxy)-1-[(acetyloxy)methyl]heptadecyl]-

CBNumber:: CB35550091

분자식:: C26H47NO7

포뮬러 무게:: 485.65

MOL 파일:: 13018-48-9.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 21

Tetraacetylphytosphingosine 속성

녹는점: 46 °C

끓는 점: 594.3±50.0 °C(Predicted)

밀도: 1.021±0.06 g/cm3(Predicted)

산도 계수 (pKa): 14.72±0.46(Predicted)

InChIKey: SGTYQWGEVAMVKB-NXCFDTQHSA-N

SMILES: C(N[C@@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)CCCCCCCCCCCCCC)(=O)C

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

그림문자(GHS):

신호 어:

Danger

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H318	눈에 심한 손상을 일으킴	심한 눈 손상 또는 자극성 물질	구분 1	위험	P280, P305+P351+P338, P310
H400	수생생물에 매우 유독함	수생 환경유해성 물질 - 급성	구분 1	경고	P273, P391, P501
H410	장기적 영향에 의해 수생생물에 매우 유독함	수생 환경유해성 물질 - 만성	구분 1	경고	P273, P391, P501

예방조치문구:

P273	환경으로 배출하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P310	즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P391	누출물을 모으시오.
P501	...에 내용물 / 용기를 폐기 하시오.

Tetraacetylphytosphingosine C화학적 특성, 용도, 생산

개요

Tetraacetylphytosphingosine (TAPS) is a sphingolipid metabolite produced by Wickerhamomyces ciferrii (also known as Hansenula ciferrii). It exerts an inhibitory action on angiogenesis through inhibition of the mitogen-activated protein kinase (MAPK) pathway and intracellular calcium increase. Therefore, TAPS was suggested as a potential treatment for angiogenesis related disorders such as arthritis, cancer and psoriasis.

생물학적 활성

Tetraacetylphytosphingosine was found to induce apoptosis in HaCaT human keratinocyte cells. In addition, it was demonstrated that TAPS synergistically increases UVB-induced apoptosis via caspase activation by regulating the level of pro-apoptotic Bax and anti-apoptotic Bcl-2 in HaCaT cells.

in vitro

Tetraacetylphytosphingosine (TAPS; 5 μM; 24 h) markedly decreases VEGF-induced chemotactic migration and capillary-like tube formation in HUVEC. It significantly inhibits VEGF-induced proteolytic enzyme production, including MMP-2, urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1). It also suppresses VEGF-induced phosphorylation of p42/44 extracellular signal-regulated kinase and c-JNK. In addition, Tetraacetylphytosphingosine abolished VEGF-induced intracellular calcium increase. In HaCaT cells, Tetraacetylphytosphingosine co-treatment synergistically increases the level of UVB-induced apoptosis via caspase activation by regulating pro-apoptotic Bax and anti-apoptotic Bcl-2 levels.

Tetraacetylphytosphingosine 준비 용품 및 원자재

원자재

준비 용품

Tetraacetylphytosphingosine 공급 업체

글로벌( 21)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	301	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21669	55
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860 +86-18080483897	sales@biopurify.com	China	3777	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	8661	58
Hebei Weibang Biotechnology Co., Ltd	+8615350571055	Sibel@weibangbio.com	China	5251	58
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.	027-65526669 17771822910	2056564811@qq.com	China	1869	58
Hubei huizepu Pharmaceutical Technology Co., Ltd	19371278702	n13164103386@163.com	China	624	58
Z-trans Biochemistry Technology (Suzhou) Co.,Ltd	0512-66317708 13372112871	huijuan@zitrans.cn	China	1282	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58