エタミフィリン 化学特性,用途語,生産方法
効能
気管支拡張薬
Originator
Dalophylline,Arnolds Veterinary
Manufacturing Process
One mol of theophylline was dissolved in a 1% aqueous solution of 1 mol of
caustic soda. One mol of β-diethylaminoethyl chloride was added, and the
mixture was boiled for 6 hours with reflux, while stirring.
The product was evaporated to dryness in vacuum, and the dry, pasty residue
was taken up in acetone, to separate the desired compound from sodium chloride associated therewith. The acetone solution was distilled to remove
solvent and 1,3-dimethyl-7-(β-diethylamino)ethylxanthine-7-(β-
(diethylamino)ethyl)theophylline was obtained as a white mass. MP: 74°C.
The product is very soluble in water, alcohol and acetone.
Therapeutic Function
Diuretic, Cardiotonic, Smooth muscle relaxant,
Respiratory stimulant
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