エンビオマイシン

エンビオマイシン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

エンビオマイシン 化学特性,用途語,生産方法

効能

抗結核薬, タンパク質合成阻害薬

説明

Enviomycin was found in the culture broth of Streptomyces griseoverticillatus var. tuberacticus by Toyo Jozo Co. in 1966 as a mixture of tuberactinomycins N and O. It is a water-soluble, basic peptide closely related to viomycin and showing selective activity against Mycobacterium species about twice as strong as that of viomycin. Enviomycin, in combination with other antituberculotic drugs, is used to treat tuberculosis caused by streptomycinresistant Mycobacterium.

Originator

Tuberactin,Toyo Jozo,Japan,1975

Manufacturing Process

Two liters of an aqueous medium consisting of glucose 3%, starch 2%, soybean meal 3% and sodium chloride 1.5% were equally divided and introduced into twenty 500-ml Erlenmeyer flasks, adjusted to pH 6, sterilized at 120°C for 30 minutes, inoculated with Streptomyces griseoverticillatus var. tuberacticus N6-130 and then rotatively shake-cultured (radius 2.5 cm, 330 rpm) at 30°C for 7 days, obtaining 1.5 liter of cultured broth containing 2,360 mcg/ml of tuberactinomycin-N.
Filtered broth was passed at 2.5 ml/min through a resin column (2.5 cm diameter, 28 cm length) packed with 150 ml of ion exchange resin Amberlite IRC-50 sodium type (Rohm and Haas Co., USA.). The column was washed with water, eluted with 0.5N HCl at a flow rate 1.3 ml/min. The eluates were fractionated each 10 ml and tuberactinomycin-N activity was found at fractions No. 45-63 observed by ultraviolet absorption method and bioassay.
The thus yielded active fraction, about 200 ml, was neutralized with sodium hydroxide, concentrated to about 15 ml in vacuo, separating the precipitated inorganic salts therefrom. After decolorization with active carbon, 150 ml of methanol was added, the mixture was allowed to stand overnight at 5°C and the precipitate was collected by filtration. The precipitate was washed withmethanol and dried in vacuo to yield crude tuberactinomycin-N hydrochloride (yield, 3.07 g; purity, 7 1.5%; recovery, 62%).

Therapeutic Function

Antitubercular

エンビオマイシン 上流と下流の製品情報

原材料

準備製品

エンビオマイシン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30250	58

33103-22-9(エンビオマイシン)キーワード:

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• 33103-22-9
• N2-[(4R)-4-Hydroxy-L-βLys-]cyclo[L-A2pr*-3-hydroxy-L-Ala-3-hydroxy-L-Ala-3-(carbamoylamino)Dha-2-[(4R)-2-amino-1,4,5,6-tetrahydropyrimidine-4-yl]-L-Gly-]
• Tuberactinomycin N
• 1-(L-Threo-3,6-diamino-4-hydroxy-hexanoic acid)-6-[T-2-(2-amino-1,4,5,6-tetrahydro-4-pyriminyl)glycine]viomycin
• Aids008855
• Aids-008855
• Tuberactin (*sulfate*)
• Turn-n
• Enviomycin
• 1,4,7,10,13-Pentaazacyclohexadecane, cyclic peptide deriv.
• enviomucin
• Tuberactinomycin N (8CI, 9CI)
• Viomycin, 1-[(3R,4R)-4-hydroxy-3,6-diaminohexanoic acid]-6-[L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)glycine]-, (R)-
• Cyclo[(2Z)-3-[(aminocarbonyl)amino]-2,3-didehydroalanyl-(2S)-2-[(4R)-2-amino-3,4,5,6-tetrahydro-4-pyrimidinyl]glycyl-(2S)-2-[[(3R,4R)-3,6-diamino-4-hydroxy-1-oxohexyl]amino]-β-alanyl-L-seryl-L-seryl]
• ツベルアクチノマイシンN
• N2-[(4R)-4-ヒドロキシ-L-βLys-]シクロ[L-A2pr*-3-ヒドロキシ-L-Ala-3-ヒドロキシ-L-Ala-3-(カルバモイルアミノ)Dha-2-[(4R)-2-アミノ-1,4,5,6-テトラヒドロピリミジン-4-イル]-L-Gly-]
• エンビオマイシン
• EVM【エンビオマイシン】
• 1-[(Z)-[2,5,9,12,15-ペンタオキソ-4-(2-イミノヘキサヒドロピリミジン-4-イル)-8-(3,6-ジアミノ-4-ヒドロキシヘキサノイルアミノ)-11,14-ビス(ヒドロキシメチル)-3,6,10,13,16-ペンタアザシクロヘキサデカン-1-イリデン]メチル]尿素
• (3R,4R)-3,6-ジアミノ-N-[(3S,9S,12S,15S)-3-[(4R)-2-アミノ-1,4,5,6-テトラヒドロピリミジン-4-イル]-6-[(カルバモイルアミノ)メチリデン]-9,12-ビス(ヒドロキシメチル)-2,5,8,11,14-ペンタオキソ-1,4,7,10,13-ペンタアザシクロヘキサデカン-15-イル]-4-ヒドロキシヘキサンアミド
• 3,6-ジアミノ-N-[(6Z)-6-[(カルバモイルアミノ)メチリデン]-9,12-ビス(ヒドロキシメチル)-3-(2-イミノ-1,3-ジアジナン-4-イル)-2,5,8,11,14-ペンタオキソ-1,4,7,10,13-ペンタアザシクロヘキサデカン-15-イル]-4-ヒドロキシヘキサンアミド
• ツベラクチノマイシンN
• ペプチド系抗生物質
• 抗結核薬