ボングクレキン酸

ボングクレキン酸 価格 もっと(5)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01LKTB5753	ボングクラキン酸 Bongkrekic Acid	11076-19-0	100μg	￥37600	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTB5753	Bongkrekic Acid Bongkrekic Acid	11076-19-0	1mg	￥294400	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01BVI1820-100	Bongkrekic Acid, Triammonium Salt	11076-19-0	100μg	￥48100	2020-09-21	購入
Sigma-Aldrich Japan	B6179	ボンクレキン酸 溶液 from Pseudomonas cocovenenans, ≥95% (HPLC), ~1?mg/mL Bongkrekic acid solution from Pseudomonas cocovenenans, ≥95% (HPLC), ~1?mg/mL	11076-19-0	0.5mg	￥113000	2024-03-01	購入
Sigma-Aldrich Japan	B6179	ボンクレキン酸 溶液 from Pseudomonas cocovenenans, ≥95% (HPLC), ~1?mg/mL Bongkrekic acid solution from Pseudomonas cocovenenans, ≥95% (HPLC), ~1?mg/mL	11076-19-0	.5mg	￥109300	2018-12-25	購入

ボングクレキン酸 化学特性,用途語,生産方法

使用

Bongkrekic acid solution has been used as an adenine nucleotide translocator (ANT) inhibitor to find out a different approach for the inhibition of oxidative phosphorylation in intact T98G cells. It has also been used as an inhibitor of the permeabilization transition pore complex (PTPC) pore and a tool to explore the role of PTPC in induction of apoptosis.

定義

ChEBI: A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group.

酵素阻害剤

This toxic tricarboxylic acid (FWfree-acid = 486.61 g/mol; CAS 11076-19-0), produced Pseudomonas cocovenenans, is a potent competitive inhibitor of the mitochondrial ATP-ADP translocator, effectively blocking nucleotide binding to the carrier. The name is derived from bongkrek, a moldy coconut product produced in Indonesia. The toxin accumulates when P. cocovenenans outgrows the mold. Klingenberg et al. investigated bongkrekate binding to mitochondrial membrane to examine the reorienting site mechanism. The inferred mode of inhibition requires bongkrekate to bind to the single carrier site only from the inner face of the mitochondrial membrane (i.e., the matrix side)). They confirmed the pH-dependent accumulation of [3H]bongkrekate inside the mitochondria which superimposes onto the binding at carrier sites. By breaking the membrane with Lubrol or sonication, binding to the carrier sites could be titrated, and a Kd value of approximately 5 x 10–8 M was determined. The presence of ADP or ATP increases the amount of binding but does not alter the Kd. [35S]Atractylate is displaced by [3H]bongkrekate at a 1:1 molar ratio; this displacement is dependent on ADP concentration with the Km = 0.5 x 10–6 M. See also Atractyloside The isomer known as isobongkrekic acid, which has a cis-double bond at the dicarboxylic acid end of the molecule, has similar biological activity. Target(s): Adenine nucleotide translocator, ADP/ATP carrier; ATPase; bromelain, stem; papain; ficain, or ficin.

ボングクレキン酸 上流と下流の製品情報

原材料

準備製品

ボングクレキン酸 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Qingdao IniKem BioPharmaTech Co.,Ltd	0532-58268780	sales@inikem.com	China	276	55
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9823	79
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18020	56
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Alta Scientific Co., Ltd.	022-6537-8550 15522853686	sales@altasci.com.cn	China	4515	55
Shenzhen Regent Biochemical Technology Co., Ltd.	0755-0755-85201366 18938635012	sales@regentsciences.com	China	9304	58

11076-19-0(ボングクレキン酸)キーワード:

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• 11076-19-0
• bongkrekic acid solution
• (2E,4Z,6R,8Z,10E,14E,17S,18Z,20E)-20-Carboxymethyl-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
• BONGKREKIC ACID
• (r-(r*,s*(e,z,z,e,e,z,e)))--trimethyl
• 2,4,8,10,14,18,20-docosaheptaenedioicacid,20-(carboxymethyl)-6-methoxy-2,5,17
• 3-carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,14,18,20-heptaen
• edioicacid
• bongkrekicaci
• 2,4,8,10,14,18,20-Docosaheptaenedioic acid, 20-(carboxymethyl)-6-methoxy-2,5,17-trimethyl-, (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-
• Bongkrekic Acid Solution (1.0mg/mL in 0.01 M Tris buffer, pH 7.5)
• Bongkrekic Acid (AS SOLUTION)
• ボンクレキン酸
• (2E,4Z,6R,8Z,10E,14E,17S,18Z,20E)-20-カルボキシメチル-6-メトキシ-2,5,17-トリメチルドコサ-2,4,8,10,14,18,20-ヘプタエン二酸
• ボングクレキン酸
• ボングクラキン酸
• ボンクレキン酸 溶液
• ボングクラキン酸, Triammonium Salt
• (2E,4Z,6R,8Z,10E,14E,17S,18Z,20E)-20-(カルボキシメチル)-6-メトキシ-2,5,17-トリメチルドコサ-2,4,8,10,14,18,20-ヘプタエン二酸
• (+)-ボングクレキン酸
• 抗細菌薬