AGK-2
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- CAS番号.
- 304896-28-4
- 化学名:
- AGK-2
- 别名:
- AGK-2;N-(キノリン-5-イル)-2-シアノ-3-[5-(2,5-ジクロロフェニル)-2-フリル]アクリルアミド;2-シアノ-3-[5-(2,5-ジクロロフェニル)フラン-2-イル]-N-(キノリン-5-イル)プロパ-2-エンアミド
- 英語名:
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
- 英語别名:
- AGK2;CS-2248;SIRT,AGK2;AGK2;AGK-2;AGK 2;SIRT2 Inhibitor, AGK2;SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem;2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide;2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide;2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide;2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-
- CBNumber:
- CB42101251
- 化学式:
- C23H13Cl2N3O2
- 分子量:
- 434.27
- MOL File:
- 304896-28-4.mol
- MSDS File:
- SDS
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AGK-2 物理性質
- 沸点 :
- 675.1±55.0 °C(Predicted)
- 比重(密度) :
- 1.445±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- room temp
- 溶解性:
- DMSO：可溶2mg/mL、透明（加温）
- 外見 :
- 黄色の固体
- 酸解離定数(Pka):
- 8.87±0.43(Predicted)
- 色:
- White to Yellow to Orange
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
A3193 |
AGK-2 >97.0%(HPLC)
AGK-2
>97.0%(HPLC) |
304896-28-4 |
5mg |
￥5900 |
2024-03-01 |
購入 |
|
東京化成工業
|
A3193 |
AGK-2 >97.0%(HPLC)
AGK-2
>97.0%(HPLC) |
304896-28-4 |
25mg |
￥20400 |
2024-03-01 |
購入 |
|
東京化成工業
|
A3193 |
AGK-2 >97.0%(HPLC)
AGK-2
>97.0%(HPLC) |
304896-28-4 |
100mg |
￥61300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A8231 |
≥97% (HPLC), powder
AGK2 ≥97% (HPLC), powder |
304896-28-4 |
5mg |
￥24500 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
A8231 |
≥97% (HPLC), powder
AGK2 ≥97% (HPLC), powder |
304896-28-4 |
25mg |
￥78100 |
2024-03-01 |
購入 |
AGK-2 化学特性,用途語,生産方法
外観
白色～黄色～黄赤色粉末～結晶
使用
AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.
生物活性
Selective inhibitor of SIRT2 (IC 50 = 3.5 μ M). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μ M. Reduces α -synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.
Biochem/physiol Actions
AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.
AGK-2 上流と下流の製品情報
原材料
準備製品
AGK-2 生産企業
Global( 112)Suppliers
304896-28-4(AGK-2)キーワード:
- 304896-28-4
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
- AGK2
- SIRT2 Inhibitor, AGK2
- 2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide
- SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem
- CS-2248
- AGK2;AGK-2;AGK 2
- 2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide USP/EP/BP
- SIRT,AGK2
- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide
- AGK-2
- N-(キノリン-5-イル)-2-シアノ-3-[5-(2,5-ジクロロフェニル)-2-フリル]アクリルアミド
- 2-シアノ-3-[5-(2,5-ジクロロフェニル)フラン-2-イル]-N-(キノリン-5-イル)プロパ-2-エンアミド