m-トルイジン 化学特性,用途語,生産方法
外観
無色～黄褐色, 澄明の液体
溶解性
エタノール及びアセトンに混和するが、水に溶けにくい。
用途
有機合成原料。
使用上の注意
不活性ガス封入
化学的特性
Colorless liquid. Slightly soluble
in water; soluble in alcohol or ether. Combustible.
使用
m-Toluidine is an intermediate in the manu facture of dyes and other chemicals.
一般的な説明
A clear colorless liquid. Flash point below 200°F. Vapors heavier than air. Toxic by inhalation, ingestion, and skin absorption in high concentrations or under prolonged exposures. Used in the manufacture of organic chemicals. Density about 8 lb / gal.
反応プロフィール
m-Toluidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253].
健康ハザード
The toxicity of m-toluidine is similar to thatof o-toluidine. The exposure routes are ingestion, inhalation, and absorption through skin.The toxic effects are methemoglobinemia,anemia, and hematuria. It metabolizes to 2-amino-4-methylphenol, the major componentexcreted in urine. Inhalation of 40-ppm concentration for an hour produced severe poi soning in humans. The oral LD50 value inmice is 740 mg/kg, which is in a range com parable to its o- and p-isomers.
The pure liquid is a mild to moderate skinirritant. Its irritating effect on the eyes ofrabbits was strong.
m-Toluidine did not induce any carcino genicity in test subjects. This finding is incontrast to its ortho-isomer. Nor did it produce any mutagenic activity.
火災危険
Special Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire.
安全性プロファイル
Poison by ingestion and
intraperitoneal routes, A skin and eye
irritant. Flammable when exposed to heat or
flame. Can react vigorously on contact with
oxidizing materials. To fight fire, use foam,
CO2, dry chemical. When heated to
decomposition it emits hghly toxic fumes of
NOx. See also ANILINE and o-TOLUIDINE.
発がん性
In an 18-month carcinogenicity diet evaluation in maleCD
rats (8000 ppm for 3 months, and then 4000 ppm for additional
15 months; or 16,000 ppm for 3 months, and then 8000
for additional 15 months), and male and female CD-1 mice
(16,000 ppm for 5 months, and then 4000 ppm in males and
8000 ppm in females for additional 13 months; or
32,000 ppm in both sexes for 5 months, and then
8000 ppm in males and 16,000 ppm in females for additional
13 months), there was no evidence of a significant increase of
incidence of any kind of tumor in the rats, and only a
significant increase in liver tumors in male mice.
純化方法
It can be purified as for aniline. Twice-distilled, m-toluidine is converted to the hydrochloride using a slight excess of HCl, and the salt is fractionally crystallised from 25% EtOH (five times), and from distilled water (twice), rejecting, in each case, the first material that crystallised out. The amine is regenerated and distilled as for o-toluidine. The benzoyl derivative has m 125o (from EtOH). [Berliner & May J Am Chem Soc 49 1007 1927, Beilstein 12 H 853, 12 I 397, 12 II 463, 12 III 1949, 12 IV 1813.]
m-トルイジン 上流と下流の製品情報
原材料
準備製品
1-(m-トリル)ピペラジン
5-メチル-1H-ベンゾトリアゾール
7-メチルキノリン
3-[[4-[(4,6-ジクロロ-1,3,5-トリアジン-2-イル)アミノ]-2-メチルフェニル]アゾ]-1,5-ナフタレンジスルホン酸二ナトリウム
N,N-ジエチル-m-トルイジン
1-メチルアミノ-4-[(3-メチルフェニル)アミノ]-9,10-アントラキノン
N-エチル-N-[4-[[4-[N-エチル-N-(3-ソジオスルホベンジル)アミノ]-2-メチルフェニル][4-(ジエチルアミノ)フェニル]メチレン]-3-メチル-2,5-シクロヘキサジエン-1-イリデン]-3-スルホナトベンゼンメタンアミニウム
3-[[4-[ベンゾイル(エチル)アミノ]-2-メチルフェニル]アゾ]-4-ヒドロキシ-1-ナフタレンスルホン酸ナトリウム
3-クロロトルエン
3,3'-[[6-[(2-ヒドロキシエチル)アミノ]-1,3,5-トリアジン-2,4-ジイル]ビス[イミノ(2-メチル-4,1-フェニレン)アゾ]]ビス[1,5-ナフタレンジスルホン酸ジナトリウム]
3,3'-[カルボニルビス[イミノ(2-メチル-4,1-フェニレン)アゾ]]ビス[1,5-ナフタレンジスルホン酸]四ナトリウム
3-フルオロトルエン
7-キノリンカルボキシアルデヒド
3-フルオロベンゾトリフルオリド
Reactive Yeiiow M-3RE
1-[[3-メチル-4-[(3-メチルフェニル)アゾ]フェニル]アゾ]-2-ナフトール
(3-メチルフェニル)カルバミド酸3-[(メトキシカルボニル)アミノ]フェニル
トロキサトン
7-キノリンカルボン酸
N-(m-トリル)ベンジルアミン
4'-ブロモ-3'-メチルアセトアニリド
2-(TRIFLUOROMETHYL)-5-METHYLQUINOLINE-4-CARBOXYLIC ACID
N-エチル-m-トルイジン