アラニジピン

アラニジピン 化学構造式
86780-90-7
CAS番号.
86780-90-7
化学名:
アラニジピン
别名:
1,4-ジヒドロ-2,6-ジメチル-4-(2-ニトロフェニル)-3,5-ピリジンジカルボン酸3-メチル5-(2-オキソプロピル);アサニジピン;アラニジピン;アラニジピン (JAN);3-メチル 5-(2-オキソプロピル) 2,6-ジメチル-4-(2-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボキシラート
英語名:
ARANIDIPINE
英語别名:
Sapresta;MPC-1304;ARANIDIPINE;Asanidipine;Aranidipine MPC1304;ARANIDIPINE USP/EP/BP;Aranidipine, 10 mM in DMSO;ARANIDIPINE MPC1304;MPC-1304;MPC 1304;Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels;3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CBNumber:
CB4386708
化学式:
C19H20N2O7
分子量:
388.37
MOL File:
86780-90-7.mol

アラニジピン 物理性質

融点 :
155°
沸点 :
530.0±50.0 °C(Predicted)
比重(密度) :
1.284±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMSO : 125 mg/mL (321.86 mM)
外見 :
Solid
酸解離定数(Pka):
2.56±0.70(Predicted)
色:
Light yellow to yellow

安全性情報

毒性 LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano)

アラニジピン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

アラニジピン 化学特性,用途語,生産方法

効能

血圧降下薬, カルシウムチャネル遮断薬

商品名

サプレスタ (大鵬薬品工業); ベック (日医工)

説明

Aranidipine was launched in Japan as an antihypertensive agent. Its pharmacological effects are similar to other dihydropyridine derivatives, e.g., nefidipine, however, it is more potent and longer lasting. This is partially due to the fact that its initial metabolite (ketone reduction) is just as effective as the parent compound. Aranidipine exerts its activity by blocking Ca+2 entry during depolarization via L-type voltagegated Ca channels. This causes decreased levels of intracellular Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a selective α2-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis. While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)- antipode.

アラニジピン 上流と下流の製品情報

原材料

準備製品


アラニジピン 生産企業

Global( 79)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783
2355560935@qq.com China 11777 60
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2110 70
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960
info@chemlin.com.cn China 16307 64
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
China 9874 58
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4853 58
Bide Pharmatech Ltd. 400-164-7117 18317119277
product02@bidepharm.com China 40000 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266
China 4865 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9799 58
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720
chaolaichem@foxmail.com China 9996 58
Shenzhen Regent Biochemical Technology Co., Ltd. 0755-85201366 18938635012
sales@regentsciences.com China 9381 58

アラニジピン  スペクトルデータ(1HNMR)


86780-90-7(アラニジピン)キーワード:


  • 86780-90-7
  • ARANIDIPINE
  • 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
  • MPC-1304
  • Sapresta
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester
  • Asanidipine
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester
  • 3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Aranidipine MPC1304
  • ARANIDIPINE MPC1304;MPC-1304;MPC 1304
  • ARANIDIPINE USP/EP/BP
  • Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels
  • Aranidipine, 10 mM in DMSO
  • 1,4-ジヒドロ-2,6-ジメチル-4-(2-ニトロフェニル)-3,5-ピリジンジカルボン酸3-メチル5-(2-オキソプロピル)
  • アサニジピン
  • アラニジピン
  • アラニジピン (JAN)
  • 3-メチル 5-(2-オキソプロピル) 2,6-ジメチル-4-(2-ニトロフェニル)-1,4-ジヒドロピリジン-3,5-ジカルボキシラート
Copyright 2017 © ChemicalBook. All rights reserved