アラニジピン 化学特性,用途語,生産方法
効能
血圧降下薬, カルシウムチャネル遮断薬
商品名
サプレスタ (大鵬薬品工業); ベック (日医工)
説明
Aranidipine was launched in Japan as an antihypertensive agent.
Its pharmacological effects are similar to other dihydropyridine derivatives, e.g.,
nefidipine, however, it is more potent and longer lasting. This is partially due to the
fact that its initial metabolite (ketone reduction) is just as effective as the parent
compound. Aranidipine exerts its activity by blocking Ca
+2 entry during depolarization
via L-type voltagegated Ca channels. This causes decreased levels of intracellular
Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a
selective α
2-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As
a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis.
While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)-
antipode.
アラニジピン 上流と下流の製品情報
原材料
準備製品