TOPO II, P170 HUMAN 化学特性,用途語,生産方法
使用
Human topoisomerase II α has been used in DNA cleavage assay.
一般的な説明
Topoisomerase II α is encoded by TOP2A gene, which is located on 17q21.2 in the human chromosome. It is essential for controlling the topological state of DNA by reversibly breaking the DNA strands during replication, recombination and transcription. TOP2A expression increases at late S phase and during G2/M of the cell cycle and decreases after mitosis. Polymorphism with TOP2A causes chromosome instability and tumorigenesis. TOP2A causes tumor proliferation and invasiveness in various cancer types like breast cancer, ovarian cancer and prostate cancer.
Biochem/physiol Actions
Used to study DNA structure and topology.
TOPO II, P170 HUMAN 上流と下流の製品情報
原材料
準備製品